Theme 3 - Modelling of spread and evolution of infectious diseases and complex networks

Maths Lead: Dr K Sharkey Health & Life Sciences Lead: Prof S O’Brien

Complex networks are ubiquitous in healthcare and medicine. Reliable and accurate network models are critical to understanding many aspects of human biology and disease development inside the body as well as the infectious disease propagation. The capability of a model to take care of large number of potential contributing factors and our ability to reduce network complexity to capture the most relevant factors are of vital importance in disease network modelling. We focus on the increasingly important area of AMR modelling.


Project 1. Mechanistic models of AMR

Academic Team (UoL): Dr K Sharkey, Prof S O’Brien, Prof F Falciani

Clinical/Industrial Team: Liverpool Health Partners, Public Health England, Bionow.


Project 2. Influenza dynamics and strain competition

Academic Team: Dr J Read (Lancaster), Dr O Karpenkov (UoL), Prof F Falciani (UoL), Prof P Diggle (Lancaster)

Clinical/Industrial Team: Public Health England


Project 3. AMR dynamics within host

Academic Team (UoL): Dr B Vasiev, Dr M Horsburgh

Clinical/Industrial Team: North West Coast AHSN, Unilever


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Typical network scenario

Project 1 - Typical network scenario

Network and graph connections

Project 2 - Network and graph connections

Modeling interactions within a cell

Project 3 - Modeling interactions within a cell

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