Publications - Liverpool Centre for Cardiovascular Science

Latest publications:

ALDH2 polymorphism and myocardial infarction: From alcohol metabolism to redox regulation.

Lamb RJ, Griffiths K, Lip GYH, Sorokin V, Frenneaux MP, Feelisch M, Madhani M.Pharmacol Ther. 2024 Jul;259:108666. doi: 10.1016/j.pharmthera.2024.108666. Epub 2024 May 17.PMID: 38763322 Free article. Review.

Multi-granularity learning of explicit geometric constraint and contrast for label-efficient medical image segmentation and differentiable clinical function assessment.

Meng Y, Zhang Y, Xie J, Duan J, Joddrell M, Madhusudhan S, Peto T, Zhao Y, Zheng Y.Med Image Anal. 2024 Jul;95:103183. doi: 10.1016/j.media.2024.103183. Epub 2024 Apr 20.PMID: 38692098 Free article.

Artificial intelligence-enhanced electrocardiogram analysis for identifying cardiac autonomic neuropathy in patients with diabetes.

Irlik K, Aldosari H, Hendel M, Kwiendacz H, Piaśnik J, Kulpa J, Ignacy P, Boczek S, Herba M, Kegler K, Coenen F, Gumprecht J, Zheng Y, Lip GYH, Alam U, Nabrdalik K.Diabetes Obes Metab. 2024 Jul;26(7):2624-2633. doi: 10.1111/dom.15578. Epub 2024 Apr 11.PMID: 38603589

This approach could be applied in large-scale screening of CAN, particularly to identify definite/severe CAN where cardiovascular risk factor modification may be initiated....

Risk of diabetic retinopathy and diabetic macular oedema with sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in type 2 diabetes: a real-world data study from a global federated database.

Eleftheriadou A, Riley D, Zhao SS, Austin P, Hernández G, Lip GYH, Jackson TL, Wilding JPH, Alam U.Diabetologia. 2024 Jul;67(7):1271-1282. doi: 10.1007/s00125-024-06132-5. Epub 2024 Apr 8.PMID: 38584180 Free PMC article.

Modifying temperature-related cardiovascular mortality through green-blue space exposure.

Hu K, Wang S, Fei F, Song J, Chen F, Zhao Q, Shen Y, Fu J, Zhang Y, Cheng J, Zhong J, Yang X, Wu J.Environ Sci Ecotechnol. 2024 Mar 7;20:100408. doi: 10.1016/j.ese.2024.100408. eCollection 2024 Jul.PMID: 38560758 Free PMC article.

A case time series approach was employed to analyse temperature-cardiovascular mortality association and the effect modifications of type-specific GBSs across 1085 subdistricts in south-eastern China. ...Notably, forests, parks, nature reserves, street greenery, and lakes …

Effect of combination pioglitazone with sodium-glucose cotransporter-2 inhibitors or glucagon-like peptide-1 receptor agonists on outcomes in type 2 diabetes: A systematic review, meta-analysis, and real-world study from an international federated database.

Anson M, Henney AE, Zhao SS, Ibarburu GH, Lip GYH, Cuthbertson DJ, Nabrdalik K, Alam U.Diabetes Obes Metab. 2024 Jul;26(7):2606-2623. doi: 10.1111/dom.15576. Epub 2024 Apr 1.PMID: 38558280

AIMS: To evaluate the efficacy and cardiovascular outcomes of combination pioglitazone with either a glucagon-like peptide-1 receptor agonist (GLP-1RA) or a sodium-glucose cotransporter-2 (SGLT2) inhibitor in individuals with type 2 diabetes (T2D) by conducting a systemati …

Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation.

Ayagama T, Charles PD, Bose SJ, Boland B, Priestman DA, Aston D, Berridge G, Fischer R, Cribbs AP, Song Q, Mirams GR, Amponsah K, Heather L, Galione A, Herring N, Kramer H, Capel RA, Platt FM, Schotten U, Verheule S, Burton RAB.iScience. 2024 Mar 28;27(6):109609. doi: 10.1016/j.isci.2024.109609. eCollection 2024 Jun 21.PMID: 38827406 Free PMC article.

How far are we from accurate sex-specific risk prediction of cardiovascular disease? One size may not fit all.

Huang B, Dalakoti M, Lip GYH.Cardiovasc Res. 2024 Jun 12:cvae135. doi: 10.1093/cvr/cvae135. Online ahead of print.PMID: 38862399 No abstract available.

Protein-nanoparticle co-assembly supraparticles for drug delivery: Ultrahigh drug loading and colloidal stability, and instant and complete lysosomal drug release.

Xu Z, Lin H, Dai J, Wen X, Yu X, Xu C, Ruan G.Int J Pharm. 2024 Jun 10;658:124231. doi: 10.1016/j.ijpharm.2024.124231. Epub 2024 May 15.PMID: 38759741

We further show that our PNCAS-based drug nano-carrier possesses a built-in environment-responsive drug release feature: once in lysosomes, the loaded drug molecules are released instantly (<1 min) and completely (100 %). Our PNCAS-based drug delivery system is spontane …

Natriuretic peptides and C-reactive protein in in heart failure and malnutrition: a systematic review and meta-analysis.

Prokopidis K, Irlik K, Ishiguchi H, Rietsema W, Lip GYH, Sankaranarayanan R, Isanejad M, Nabrdalik K.ESC Heart Fail. 2024 Jun 8. doi: 10.1002/ehf2.14851. Online ahead of print.PMID: 38850122 Free article.

METHODS: From inception until July 2023, the databases, PubMed, Scopus, Web of Science, and Cochrane Library were searched. To examine the association among malnutrition [controlling nutritional status (CONUT) score 2; Geriatric Nutritional Risk Index (GNRI) score <92] …

Phenotypes of Polish primary care patients using hierarchical clustering: Exploring the risk of mortality in the LIPIDOGEN2015 study cohort.

Chen Y, Gue Y, Banach M, Mikhailidis D, Toth PP, Gierlotka M, Osadnik T, Golawski M, Tomasik T, Windak A, Jozwiak J, Lip GYH; LIPIDOGRAM Investigators.Eur J Clin Invest. 2024 Jun 8:e14261. doi: 10.1111/eci.14261. Online ahead of print.PMID: 38850064

Exercise improves surrogate measures of liver histological response in metabolic dysfunction-associated steatotic liver disease.

Cuthbertson DJ, Keating SE, Pugh CJA, Owen PJ, Kemp GJ, Umpleby M, Geyer NG, Chinchilli VM, Stine JG.Liver Int. 2024 Jun 7. doi: 10.1111/liv.15947. Online ahead of print.PMID: 38847589

Cardiac resynchronization therapy (CRT) non-responders in the contemporary era: A State-of-the-Art review.

Gerra L, Bonini N, Mei DA, Imberti JF, Vitolo M, Bucci T, Boriani G, Lip GYH.Heart Rhythm. 2024 Jun 5:S1547-5271(24)02670-5. doi: 10.1016/j.hrthm.2024.05.057. Online ahead of print.PMID: 38848860 Free article. Review.

Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines.

Gardner J, Abrams ST, Toh CH, Parker AL, Lovatt C, Nicolson PLR, Watson SP, Grice S, Hering L, Pirmohamed M, Naisbitt DJ.NPJ Vaccines. 2024 Jun 5;9(1):99. doi: 10.1038/s41541-024-00895-z.PMID: 38839821 Free PMC article.

Meta-analysis of clinical and safety profiles after reperfusion therapy in acute posterior circulation strokes: insights and implications.

Chowdhury A, Killingsworth MC, Calic Z, Bhaskar SM.Acta Radiol. 2024 Jun 5:2841851241255313. doi: 10.1177/02841851241255313. Online ahead of print.PMID: 38839085

Developing technologies to assess vascular ageing: a roadmap from VascAgeNet.

Zanelli S, Agnoletti D, Alastruey J, Allen J, Bianchini E, Bikia V, Boutouyrie P, Bruno RM, Climie R, Djamaleddine D, Gkaliagkousi E, Giudici A, Gopcevic K, Grillo A, Guala A, Hametner B, Joseph J, Karimpour P, Kodithuwakku V, Kyriacou PA, Lazaridis A, Lonnebakken MT, Martina MR, Mayer CC, Nabeel PM, Navickas P, Nemcsik J, Orter S, Park C, Pereira T, Pucci G, Amado Rey AB, Salvi P, Gonçalves Seabra AC, Seeland U, van Sloten T, Spronck B, Stansby G, Steens I, Stieglitz T, Tan I, Veerasingam D, Wassertheurer S, Weber T, Westerhof BE, Charlton PH.Physiol Meas. 2024 Jun 5. doi: 10.1088/1361-6579/ad548e. Online ahead of print.PMID: 38838703

Measurements of vascular ageing are emerging as markers of cardiovascular risk, with potential applications in disease diagnosis and prognosis, and for guiding treatments. ...#

DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases.

Handelsman Y, Anderson JE, Bakris GL, Ballantyne CM, Bhatt DL, Bloomgarden ZT, Bozkurt B, Budoff MJ, Butler J, Cherney DZI, DeFronzo RA, Del Prato S, Eckel RH, Filippatos G, Fonarow GC, Fonseca VA, Garvey WT, Giorgino F, Grant PJ, Green JB, Greene SJ, Groop PH, Grunberger G, Jastreboff AM, Jellinger PS, Khunti K, Klein S, Kosiborod MN, Kushner P, Leiter LA, Lepor NE, Mantzoros CS, Mathieu C, Mende CW, Michos ED, Morales J, Plutzky J, Pratley RE, Ray KK, Rossing P, Sattar N, Schwarz PEH, Standl E, Steg PG, Tokgözoğlu L, Tuomilehto J, Umpierrez GE, Valensi P, Weir MR, Wilding J, Wright EE Jr.Metabolism. 2024 Jun 4:155931. doi: 10.1016/j.metabol.2024.155931. Online ahead of print.PMID: 38852020 Free article. Review.

The spectrum of cardiorenal and metabolic diseases comprises many disorders, including obesity, type 2 diabetes (T2D), chronic kidney disease (CKD), atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), dyslipidemias, hypertension, and associated comorbiditie …

Global Consensus Recommendations on Improving the Safety of Chronic Total Occlusion Interventions.

Wu EB, Kalyanasundaram A, Brilakis ES, Mashayekhi K, Tsuchikane E; CTO Global Consensus Group.Heart Lung Circ. 2024 Jun 4:S1443-9506(24)00366-4. doi: 10.1016/j.hlc.2023.11.030. Online ahead of print.PMID: 38839467 Free article.

Association between cumulative uric acid exposure and the risk of incident cardiac conduction block.

Li N, Cui L, Korantzopoulos P, Zhang N, Shu R, Song H, Wang J, Chen S, Lip GYH, Tse G, Letsas KP, Bazoukis G, Yan GX, Yang X, Wu S, Liu T.Cardiovasc Res. 2024 Jun 4:cvae115. doi: 10.1093/cvr/cvae115. Online ahead of print.PMID: 38830012 No abstract available.

Social determinants of health and clinical outcomes among patients with atrial fibrillation: evidence from a global federated health research network.

Simoni AH, Bucci T, Romiti GF, Frydenlund J, Johnsen SP, Abdul-Rahim AH, Lip GYH.QJM. 2024 Jun 4;117(5):353-359. doi: 10.1093/qjmed/hcad275.PMID: 38060301 Free PMC article.

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