2024
Brennan, S., Chen, S., Makwana, S., Esposito, S., McGuinness, L. R., Alnaimi, A. I. M., . . . Rainbow, R. D. (2024). Identification and characterisation of functional K<sub>ir</sub>6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane.. British journal of pharmacology. doi:10.1111/bph.16390DOI: 10.1111/bph.16390
2023
Stewart, A. J., Tuncay, E., Pitt, S. J., & Rainbow, R. D. (2023). Editorial: Insulin resistance and cardiovascular disease. FRONTIERS IN ENDOCRINOLOGY, 14. doi:10.3389/fendo.2023.1266173DOI: 10.3389/fendo.2023.1266173
Brennan, S., Alnaimi, A. I. M., Mcguinness, L. R., Abdelaziz, M. I. M., Mckenzie, R. A., Draycott, S., . . . Rainbow, R. D. (2023). Slowly activating voltage-gated potassium current potentiation by ML277 is a novel cardioprotective intervention. PNAS NEXUS, 2(5). doi:10.1093/pnasnexus/pgad156DOI: 10.1093/pnasnexus/pgad156
Roberts, J. A., Rainbow, R. D., & Sharma, P. (2023). Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(7). doi:10.3390/ijms24076723DOI: 10.3390/ijms24076723
2022
Morris, G. E., Denniff, M. J., Karamanavi, E., Andrews, S. A., Kostogrys, R. B., Bountziouka, V., . . . Webb, T. R. (2022). The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1. BRITISH JOURNAL OF PHARMACOLOGY, 179(21), 4958-4973. doi:10.1111/bph.15921DOI: 10.1111/bph.15921
Does imipramine cause detubulation of adult rat ventricular cardiomyocytes resulting in contractile failure and a phenotype akin to drug-induced heart failure? (Conference Paper)
McGuinness, L. R., Mahaut-Smith, M., & Rainbow, R. D. (2022). Does imipramine cause detubulation of adult rat ventricular cardiomyocytes resulting in contractile failure and a phenotype akin to drug-induced heart failure?. In ACTA PHYSIOLOGICA Vol. 236 (pp. 913-915). Retrieved from https://www.webofscience.com/
Doxorubicin mediated impairment of vascular tone and recovery by NRF2 antioxidant pathway activator CDDO. (Conference Paper)
Verma, A., Sharma, P., & Rainbow, R. D. (2022). Doxorubicin mediated impairment of vascular tone and recovery by NRF2 antioxidant pathway activator CDDO.. In ACTA PHYSIOLOGICA Vol. 236 (pp. 879-881). Retrieved from https://www.webofscience.com/
Identification of differentially expressed genes and functional activity of ion channels and receptors in rat vascular tissues (Conference Paper)
Alanazi, F. M., Sharma, P., & Rainbow, R. D. (2022). Identification of differentially expressed genes and functional activity of ion channels and receptors in rat vascular tissues. In ACTA PHYSIOLOGICA Vol. 236 (pp. 881). Retrieved from https://www.webofscience.com/
Remote Ischaemic Conditioned Serum From Humans Blocks Stretch-Induced Hypertrophy of Adult Rat Ventricular Cardiomyocytes (Conference Paper)
Abdelaziz, M. I. M., Brennan, S., Squire, I. B., Willets, J. M., Rodrigo, G. C., & Rainbow, R. D. (2022). Remote Ischaemic Conditioned Serum From Humans Blocks Stretch-Induced Hypertrophy of Adult Rat Ventricular Cardiomyocytes. In ACTA PHYSIOLOGICA Vol. 236 (pp. 627-629). Retrieved from https://www.webofscience.com/
Selective PKC inhibition switches time-dependent glucose cardiotoxicity to cardioprotection. (Conference Paper)
Brennan, S., Esposito, S., Abdelaziz, M. I., Martin, C. A., Makwana, S., Sims, M. W., . . . Rainbow, R. D. (2022). Selective PKC inhibition switches time-dependent glucose cardiotoxicity to cardioprotection.. In ACTA PHYSIOLOGICA Vol. 236 (pp. 587-589). Retrieved from https://www.webofscience.com/
Alnaimi, A. I., Brennan, S., Rainbow, R., & Sharma, P. (2022). THE CARDIOPROTECTIVE ROLE OF IKS POTENTIATION AGANIST ISCHAEMIC INJURY. In ACTA PHYSIOLOGICA Vol. 236 (pp. 945). Retrieved from https://www.webofscience.com/
Brennan, S., Esposito, S., Abdelaziz, M. I. M., Martin, C. A. A., Makwana, S., Sims, M. W. W., . . . Rainbow, R. D. (2022). Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection. FRONTIERS IN CARDIOVASCULAR MEDICINE, 9. doi:10.3389/fcvm.2022.997013DOI: 10.3389/fcvm.2022.997013
SVEP1 is a new regulator of arterial tone (Conference Paper)
Morris, G. E., Denniff, M. J., Kostogrys, R. B., Bountziouka, V., Rainbow, R. D., Samani, N. J., & Webb, T. R. (2022). SVEP1 is a new regulator of arterial tone. In CARDIOVASCULAR RESEARCH Vol. 118. doi:10.1093/cvr/cvac066.209DOI: 10.1093/cvr/cvac066.209
2021
Bentley, R., Logantha, S. J. R. J., Sharma, P., Rainbow, R. R., & Lip, G. Y. H. (2021). Pathophysiological insights into atrial fibrillation: revisiting the electrophysiological substrate, anatomical substrate, and possible insights from proteomics. CARDIOVASCULAR RESEARCH, 117(3), E41-E45. doi:10.1093/cvr/cvaa276DOI: 10.1093/cvr/cvaa276
2020
Brennan, S., Rubaiy, H. N., Imanzadeh, S., Reid, R., Lodwick, D., Norman, R. I., & Rainbow, R. D. (2020). Kir6.2-D323 and SUR2A-Q1336: an intersubunit interaction pairing for allosteric information transfer in the K<sub>ATP</sub> channel complex. BIOCHEMICAL JOURNAL, 477(3), 671-689. doi:10.1042/BCJ20190753DOI: 10.1042/bcj20190753
Celik, N., O’Brien, F., Brennan, S., Rainbow, R. D., Dart, C., Zheng, Y., . . . Barrett-Jolley, R. (2020). Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data. Communications Biology, 3, 1-10. doi:10.1038/s42003-019-0729-3DOI: 10.1038/s42003-019-0729-3
2019
Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data (Journal article)
Celik, N., O’Brien, F., Brennan, S., Rainbow, R., Dart, C., Zheng, Y., . . . Barrett-Jolley, R. (n.d.). Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data. BioRxiv. doi:10.1101/767418DOI: 10.1101/767418
Brennan, S., Chen, S., Makwana, S., Martin, C. A., Sims, M. W., Alonazi, A. S. A., . . . Rainbow, R. D. (2019). A novel form of glycolytic metabolism-dependent cardioprotection revealed by PKCα and β inhibition. JOURNAL OF PHYSIOLOGY-LONDON, 597(17), 4481-4501. doi:10.1113/JP278332DOI: 10.1113/JP278332
2018
Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions (Journal article)
Rainbow, R. D., Brennan, S., Jackson, R., Beech, A. J., Bengreed, A., Waldschmidt, H. V., . . . Willets, J. M. (2018). Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions. MOLECULAR PHARMACOLOGY, 94(3), 1079-1091. doi:10.1124/mol.118.112524DOI: 10.1124/mol.118.112524
2016
Distinct and complementary roles for alpha and beta isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose (Journal article)
Jackson, R., Brennan, S., Fielding, P., Sims, M. W., Challiss, R. A. J., Adlam, D., . . . Rainbow, R. D. (2016). Distinct and complementary roles for alpha and beta isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose. BRITISH JOURNAL OF PHARMACOLOGY, 173(5), 870-887. doi:10.1111/bph.13399DOI: 10.1111/bph.13399
Response to Qian and Colvin: Zinc-mediated Regulation of the Cardiac Ryanodine Receptor Occurs via Multiple Binding Sites (Journal article)
Woodier, J., Rainbow, R. D., Stewart, A. J., & Pitt, S. J. (2016). Response to Qian and Colvin: Zinc-mediated Regulation of the Cardiac Ryanodine Receptor Occurs via Multiple Binding Sites. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(8), 4267. doi:10.1074/jbc.L115.713214DOI: 10.1074/jbc.L115.713214
Detachment of surface membrane invagination systems by cationic amphiphilic drugs (Journal article)
Osman, S., Taylor, K. A., Allcock, N., Rainbow, R. D., & Mahaut-Smith, M. P. (2016). Detachment of surface membrane invagination systems by cationic amphiphilic drugs. Scientific Reports, 6. doi:10.1038/srep18536DOI: 10.1038/srep18536
2015
Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension (Journal article)
Willets, J. M., Nash, C. A., Rainbow, R. D., Nelson, C. P., & Challiss, R. A. J. (2015). Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension. American Journal of Physiology: Cell Physiology, 309(3), C179-C189. doi:10.1152/ajpcell.00079.2015DOI: 10.1152/ajpcell.00079.2015
Intracellular Zinc Modulates Cardiac Ryanodine Receptor-mediated Calcium Release (Journal article)
Woodier, J., Rainbow, R. D., Stewart, A. J., & Pitt, S. J. (2015). Intracellular Zinc Modulates Cardiac Ryanodine Receptor-mediated Calcium Release. JOURNAL OF BIOLOGICAL CHEMISTRY, 290(28), 17599-17610. doi:10.1074/jbc.M115.661280DOI: 10.1074/jbc.M115.661280
Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection (Journal article)
Brennan, S., Jackson, R., Patel, M., Sims, M. W., Hudman, D., Norman, R. I., . . . Rainbow, R. D. (2015). Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 79, 42-53. doi:10.1016/j.yjmcc.2014.10.016DOI: 10.1016/j.yjmcc.2014.10.016
Panhwar, F., Rainbow, R. D., Jackson, R., & Davies, N. W. (2015). Ca2+ dependent but PKC independent signalling mediates UTP induced contraction of rat mesenteric arteries.. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 51, 58-69. doi:10.1540/jsmr.51.58DOI: 10.1540/jsmr.51.58
2014
Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge (Journal article)
Lodwick, D., Rainbowl, R. D., Rubaiy, H. N., Al Johi, M., Vuister, G. W., & Norman, R. I. (2014). Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge. BIOCHEMICAL JOURNAL, 464, 343-354. doi:10.1042/BJ20140273DOI: 10.1042/BJ20140273
PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function (Journal article)
Sims, M. W., Winter, J., Brennan, S., Norman, R. I., Ng, G. A., Squire, I. B., & Rainbow, R. D. (2014). PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function. American Journal of Physiology: Heart and Circulatory Physiology, 307(04), H587-H597. doi:10.1152/ajpheart.00894.2013DOI: 10.1152/ajpheart.00894.2013
2013
Kir6.2 limits Ca<SUP>2+</SUP> overload and mitochondrial oscillations of ventricular myocytes in response to metabolic stress (Journal article)
Storey, N. M., Stratton, R. C., Rainbow, R. D., Standen, N. B., & Lodwick, D. (2013). Kir6.2 limits Ca<SUP>2+</SUP> overload and mitochondrial oscillations of ventricular myocytes in response to metabolic stress. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 305(10), H1508-H1518. doi:10.1152/ajpheart.00540.2013DOI: 10.1152/ajpheart.00540.2013
A Cytoplasmic Inter-Subunit Salt Bridge, Kir6.1R347/SUR2AE1318, Contributes to Allosteric Information Transmission in Kir6.14/SUR2A4 Channel Complexes (Journal article)
Rubaiy, H. N., Rainbow, R. D., Lodwick, D., & Norman, R. I. (2013). A Cytoplasmic Inter-Subunit Salt Bridge, Kir6.1R347/SUR2AE1318, Contributes to Allosteric Information Transmission in Kir6.14/SUR2A4 Channel Complexes. Biophysical Journal, 104(2), 131a. doi:10.1016/j.bpj.2012.11.749DOI: 10.1016/j.bpj.2012.11.749
A Single Point Mutation in the Distal C-Terminal of the Pore Forming Kir6.1 Subunit Modifies ATP-Sensitive Potassium (KATP) Channel Regulation (Journal article)
Rubaiy, H. N., Rainbow, R. D., Lodwick, D., & Norman, R. I. (2013). A Single Point Mutation in the Distal C-Terminal of the Pore Forming Kir6.1 Subunit Modifies ATP-Sensitive Potassium (KATP) Channel Regulation. Biophysical Journal, 104(2), 130a-131a. doi:10.1016/j.bpj.2012.11.748DOI: 10.1016/j.bpj.2012.11.748
Combined calcium fluorescence recording with ionic currents in contractile cells (Journal article)
Rainbow, R. D. (2013). Combined calcium fluorescence recording with ionic currents in contractile cells. Methods in Molecular Biology, 937, 149-160. doi:10.1007/978-1-62703-86-1_8DOI: 10.1007/978-1-62703-86-1_8
Selective Inhibition of PKCa and β Attenuates Glucose-Induced Potentiation of Vasoconstriction in Human Internal Mammary Arteries (Conference Paper)
Jackson, R., Adlam, D., Squire, L. B., & Rainbow, R. D. (2013). Selective Inhibition of PKCa and β Attenuates Glucose-Induced Potentiation of Vasoconstriction in Human Internal Mammary Arteries. In CIRCULATION Vol. 128. Retrieved from https://www.webofscience.com/
2011
Principal role of adenylyl cyclase 6 in K<SUP>+</SUP> channel regulation and vasodilator signalling in vascular smooth muscle cells (Journal article)
Nelson, C. P., Rainbow, R. D., Brignell, J. L., Perry, M. D., Willets, J. M., Davies, N. W., . . . Challiss, R. A. J. (2011). Principal role of adenylyl cyclase 6 in K<SUP>+</SUP> channel regulation and vasodilator signalling in vascular smooth muscle cells. CARDIOVASCULAR RESEARCH, 91(4), 694-702. doi:10.1093/cvr/cvr137DOI: 10.1093/cvr/cvr137
Protein kinase C-independent inhibition of arterial smooth muscle K<SUP>+</SUP> channels by a diacylglycerol analogue (Journal article)
Rainbow, R. D., Parker, A. M., & Davies, N. W. (2011). Protein kinase C-independent inhibition of arterial smooth muscle K<SUP>+</SUP> channels by a diacylglycerol analogue. BRITISH JOURNAL OF PHARMACOLOGY, 163(4), 845-856. doi:10.1111/j.1476-5381.2011.01268.xDOI: 10.1111/j.1476-5381.2011.01268.x
Sulphonylurea Receptors Regulate Kir6.2 Subunits Allosterically via a Salt Bridge in Cardiac KATP Channels (Journal article)
Rubaiy, H. N., Rainbow, R. D., Lodwick, D., & Norman, R. I. (2011). Sulphonylurea Receptors Regulate Kir6.2 Subunits Allosterically via a Salt Bridge in Cardiac KATP Channels. Biophysical Journal, 100(3), 432a. doi:10.1016/j.bpj.2010.12.2553DOI: 10.1016/j.bpj.2010.12.2553
2010
A study of cloned and native KATP channels in HEK 293 cells and rat ventricular myocytes. (Journal article)
Rainbow, R. D. (2010). A study of cloned and native KATP channels in HEK 293 cells and rat ventricular myocytes..
2009
Endothelin-I and angiotensin II inhibit arterial voltage-gated K<SUP>+</SUP> channels through different protein kinase C isoenzymes (Journal article)
Rainbow, R. D., Norman, R. I., Everitt, D. E., Brignell, J. L., Davies, N. W., & Standen, N. B. (2009). Endothelin-I and angiotensin II inhibit arterial voltage-gated K<SUP>+</SUP> channels through different protein kinase C isoenzymes. CARDIOVASCULAR RESEARCH, 83(3), 493-500. doi:10.1093/cvr/cvp143DOI: 10.1093/cvr/cvp143
Comparison of IP3R and RyR Expression and Ca2+ Release Characteristics in Isolated Cardiac Nuclei (Journal article)
Currie, S., Rainbow, R. D., Ewart, M. -A., & McCarron, J. G. (2009). Comparison of IP3R and RyR Expression and Ca2+ Release Characteristics in Isolated Cardiac Nuclei. Biophysical Journal, 96(3), 97a. doi:10.1016/j.bpj.2008.12.410DOI: 10.1016/j.bpj.2008.12.410
The sarcoplasmic reticulum Ca<SUP>2+</SUP> store arrangement in vascular smooth muscle (Journal article)
Rainbow, R. D., MacMillan, D., & McCarron, J. G. (2009). The sarcoplasmic reticulum Ca<SUP>2+</SUP> store arrangement in vascular smooth muscle. CELL CALCIUM, 46(5-6), 313-322. doi:10.1016/j.ceca.2009.09.001DOI: 10.1016/j.ceca.2009.09.001
2008
IP<sub>3</sub>R-mediated Ca<SUP>2+</SUP> release is modulated by anandamide in isolated cardiac nuclei (Journal article)
Currie, S., Rainbow, R. D., Ewart, M. -A., Kitson, S., Herradon Pliego, E., Kane, K. A., & McCarron, J. G. (2008). IP<sub>3</sub>R-mediated Ca<SUP>2+</SUP> release is modulated by anandamide in isolated cardiac nuclei. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 45(6), 804-811. doi:10.1016/j.yjmcc.2008.07.005DOI: 10.1016/j.yjmcc.2008.07.005
2007
Ins(1,4,5)<i>P</i><sub>3</sub> receptor regulation during 'quantal' Ca<SUP>2+</SUP> release in smooth muscle (Journal article)
McCarron, J. G., Olson, M. L., Rainbow, R. D., MacMillan, D., & Chalmers, S. (2007). Ins(1,4,5)<i>P</i><sub>3</sub> receptor regulation during 'quantal' Ca<SUP>2+</SUP> release in smooth muscle. TRENDS IN PHARMACOLOGICAL SCIENCES, 28(6), 271-279. doi:10.1016/j.tips.2007.04.007DOI: 10.1016/j.tips.2007.04.007
Ion channels in smooth muscle: Regulation by the sarcoplasmic reticulum and mitochondria (Journal article)
Chalmers, S., Olson, M. L., MacMillan, D., Rainbow, R. D., & McCarron, J. G. (2007). Ion channels in smooth muscle: Regulation by the sarcoplasmic reticulum and mitochondria. CELL CALCIUM, 42(4-5), 447-466. doi:10.1016/j.ceca.2007.05.010DOI: 10.1016/j.ceca.2007.05.010
2006
Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells (Journal article)
Rainbow, R. D., Hardy, M. E. L., Standen, N. B., & Davies, N. W. (2006). Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells. JOURNAL OF PHYSIOLOGY-LONDON, 575(3), 833-844. doi:10.1113/jphysiol.2006.114009DOI: 10.1113/jphysiol.2006.114009
2005
Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K<sub>ATP</sub> channels during metabolic stress (Journal article)
Rainbow, R. D., Norman, R. I., Hudman, D., Davies, N. W., & Standen, N. B. (2005). Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K<sub>ATP</sub> channels during metabolic stress. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 39(4), 637-646. doi:10.1016/j.yjmcc.2005.06.017DOI: 10.1016/j.yjmcc.2005.06.017
2004
SUR2A C-terminal fragments reduce K<sub>ATP</sub> currents and ischaemic tolerance of rat cardiac myocytes (Journal article)
Rainbow, R. D., Lodwick, D., Hudman, D., Davies, N. W., Norman, R. I., & Standen, N. B. (2004). SUR2A C-terminal fragments reduce K<sub>ATP</sub> currents and ischaemic tolerance of rat cardiac myocytes. JOURNAL OF PHYSIOLOGY-LONDON, 557(3), 785-794. doi:10.1113/jphysiol.2004.061655DOI: 10.1113/jphysiol.2004.061655
Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in K<sub>ATP</sub> channels (Journal article)
Rainbow, R. D., James, M., Hudman, D., Al Johi, M., Singh, H., Watson, P. J., . . . Norman, R. I. (2004). Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in K<sub>ATP</sub> channels. BIOCHEMICAL JOURNAL, 379, 173-181. doi:10.1042/BJ20031087DOI: 10.1042/BJ20031087
2003
Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes (Journal article)
Singh, H., Hudman, D., Lawrence, C. L., Rainbow, R. D., Lodwick, D., & Norman, R. I. (2003). Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 35(5), 445-459. doi:10.1016/S0022-2828(03)00041-5DOI: 10.1016/S0022-2828(03)00041-5
2002
The origin of calcium overload in rat cardiac myocytes following metabolic inhibition with 2,4-dinitrophenol (Journal article)
Hudman, D., Rainbow, R. D., Lawrence, C. L., & Standen, N. B. (2002). The origin of calcium overload in rat cardiac myocytes following metabolic inhibition with 2,4-dinitrophenol. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 34(7), 859-871. doi:10.1006/jmcc.2002.2024DOI: 10.1006/jmcc.2002.2024
Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K<sub>ATP</sub> channels (Journal article)
Lawrence, C. L., Rainbow, R. D., Davies, N. W., & Standen, N. B. (2002). Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K<sub>ATP</sub> channels. BRITISH JOURNAL OF PHARMACOLOGY, 136(5), 746-752. doi:10.1038/sj.bjp.0704770DOI: 10.1038/sj.bjp.0704770
