Dr Lesley Iwanejko PhD GDL BVC PGCertHE SFHEA
Senior Lecturer in Genetics Musculoskeletal & Ageing Science
- +44 (0)151 794 4242 / +44 (0)151 794 9078 / +44 (0)151 795 0381
- Work email Iwanejko@liverpool.ac.uk
- Personal Websitehttps://www.liverpool.ac.uk/literature-and-science/
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Publications
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2022
Altered oxidative DNA damage repair systems in muscles of old mice: role in the age-related increase in muscle production of cytokines/chemokines (Journal article)
Kumiscia, K., Shigdar, S., Owen, E., Staunton, C. A., Proctor, C. J., Jackson, M. J., . . . McArdle, A. (2022). Altered oxidative DNA damage repair systems in muscles of old mice: role in the age-related increase in muscle production of cytokines/chemokines. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.R44042021
Development of age-related loss of muscle mass and function - role of oxidative DNA damage repair systems (Conference Paper)
Kumiscia, K., Shigdar, S., Proctor, C., Shanley, D., Owen, E., Staunton, C., . . . McArdle, A. (2021). Development of age-related loss of muscle mass and function - role of oxidative DNA damage repair systems. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 165. doi:10.1016/j.freeradbiomed.2020.12.339Development of age-related loss of muscle mass and function – role of oxidative DNA damage repair systems (Journal article)
Kumiscia, K., Shigdar, S., Proctor, C., Shanley, D., Owen, E., Staunton, C., . . . McArdle, A. (2021). Development of age-related loss of muscle mass and function – role of oxidative DNA damage repair systems. Free Radical Biology and Medicine, 165, 30-31. doi:10.1016/j.freeradbiomed.2020.12.3352020
Role of 8-oxoG repair in the development of age-related loss of muscle mass and function (Conference Paper)
Kumiscia, K., McArdle, A., & Iwanejko, L. (2020). Role of 8-oxoG repair in the development of age-related loss of muscle mass and function. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 159 (pp. S43-S44). doi:10.1016/j.freeradbiomed.2020.10.1232018
17-(Allylamino)-17demethoxygeldanamycin reduces Endoplasmic Reticulum (ER) stress-induced mitochondrial dysfunction in C2C12 myotubes (Preprint)
2016
Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression (Journal article)
Goljanek-Whysall, K., Iwanejko, L. A., Vasilaki, A., Pekovic-Vaughan, V., & McDonagh, B. (2016). Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression. MAMMALIAN GENOME, 27(7-8), 341-357. doi:10.1007/s00335-016-9643-xFEASIBILITY STUDY OF VOLATILE ORGANIC COMPOUNDS IN CONSTIPATION IN PARKINSON'S DISEASE (Conference Paper)
Qureshi, S., Bond, A., Iwanejko, L., & Probert, C. (2016). FEASIBILITY STUDY OF VOLATILE ORGANIC COMPOUNDS IN CONSTIPATION IN PARKINSON'S DISEASE. In GUT Vol. 65 (pp. A125-A126). doi:10.1136/gutjnl-2016-312388.2242014
Glycosylated yellow laccases of the basidiomycete Stropharia aeruginosa (Journal article)
Daroch, M., Houghton, C. A., Moore, J. K., Wilkinson, M. C., Carnell, A. J., Bates, A. D., & Iwanejko, L. A. (2014). Glycosylated yellow laccases of the basidiomycete Stropharia aeruginosa. Enzyme and Microbial Techenology, 58-59, 1-7. doi:10.1016/j.enzmictec.2014.02.003Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle (Journal article)
Cobley, J. N., Sakellariou, G. K., Owens, D. J., Murray, S., Waldron, S., Gregson, W., . . . Close, G. L. (2014). Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle. Free Radical Biology and Medicine, 70, 23-32. doi:10.1016/j.freeradbiomed.2014.02.0042013
Purification, characterisation and expression in Saccharomyces cerevisiae of LipG7 an enantioselective, cold-adapted lipase from the Antarctic filamentous fungus Geomyces sp. P7 with unusual thermostability characteristics. (Journal article)
Florczak, T., Daroch, M., Wilkinson, M. C., Białkowska, A., Bates, A. D., Turkiewicz, M., & Iwanejko, L. A. (2013). Purification, characterisation and expression in Saccharomyces cerevisiae of LipG7 an enantioselective, cold-adapted lipase from the Antarctic filamentous fungus Geomyces sp. P7 with unusual thermostability characteristics.. Enzyme and microbial technology, 53(1), 18-24. doi:10.1016/j.enzmictec.2013.03.0212012
Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine † (Journal article)
Bhamra, I., Compagnone-Post, P., O’Neil, I. A., Iwanejko, L. A., Bates, A. D., & Cosstick, R. (2012). Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine †. Nucleic Acids Research, 40(21), 11126-11138. doi:10.1093/nar/gks799Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine. (Journal article)
Bhamra, I., Compagnone-Post, P., O'Neil, I. A., Iwanejko, L. A., Bates, A. D., & Cosstick, R. (2012). Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine.. Nucleic acids research, 40(21), 11126-11138. doi:10.1093/nar/gks7992006
Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age (Journal article)
Vasilaki, A., McArdle, F., Iwanejko, L. M., & McArdle, A. (2006). Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age. MECHANISMS OF AGEING AND DEVELOPMENT, 127(11), 830-839. doi:10.1016/j.mad.2006.08.0042005
Fact and artefact:: poetry, science, and a few thoughts on Ian!McEwan's <i>Saturday</i> (Journal article)
Rees-Jones, D. (2005). Fact and artefact:: poetry, science, and a few thoughts on Ian!McEwan's <i>Saturday</i>. INTERDISCIPLINARY SCIENCE REVIEWS, 30(4), 331-340. doi:10.1179/030801805X649152004
Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice (Journal article)
McArdle, F., Spiers, S., Aldemir, H., Vasilaki, A., Beaver, A., Iwanejko, L., . . . Jackson, M. J. (2004). Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice. JOURNAL OF PHYSIOLOGY-LONDON, 561(1), 233-244. doi:10.1113/jphysiol.2004.0699142003
Skeletal muscles of aged male mice fail to adapt following contractile activity (Journal article)
Vasilaki, A., Iwanejko, L., McArdle, F., Broome, C. S., Jackson, M. J., & McArdle, A. (2003). Skeletal muscles of aged male mice fail to adapt following contractile activity. BIOCHEMICAL SOCIETY TRANSACTIONS, 31, 455-456. doi:10.1042/BST0310455Age-related hotspots of oxidative damage in yeast genomic and mitochondrial DNA (Journal article)
Cheng, L., Parry, D., Strike, P., & Iwanejko, L. (2003). Age-related hotspots of oxidative damage in yeast genomic and mitochondrial DNA. Yeast, 20, S306.2002
Adaptation in skeletal muscle of mice following exercise: The effect of age and gender (Journal article)
Vasilaki, A., Iwanejko, L., Jackson, M. J., & McArdle, A. (2002). Adaptation in skeletal muscle of mice following exercise: The effect of age and gender. FASEB JOURNAL, 16(4), A392. Retrieved from https://www.webofscience.com/Mechanisms responsible for attenuated adaptive responses in skeletal muscle of aged mice following contractile activity (Journal article)
Vasilaki, A., Iwanejko, L., McArdle, F., Jackson, M. J., & McArdle, A. (2002). Mechanisms responsible for attenuated adaptive responses in skeletal muscle of aged mice following contractile activity. JOURNAL OF PHYSIOLOGY-LONDON, 543, 100P-101P. Retrieved from https://www.webofscience.com/1999
Disruption and functional analysis of seven ORFs on chromosome IV: YDL057w, YDL012c, YDL010w, YDL009c, YDL008w (APC11), YDL005c (MED2) and YDL003w (MCD1). (Journal article)
Smith, K. N., Iwanejko, L., Loeillet, S., Fabre, F., & Nicolas, A. (1999). Disruption and functional analysis of seven ORFs on chromosome IV: YDL057w, YDL012c, YDL010w, YDL009c, YDL008w (APC11), YDL005c (MED2) and YDL003w (MCD1).. Yeast (Chichester, England), 15(12), 1255-1267. doi:3.0.co;2-l">10.1002/(sici)1097-0061(19990915)15:12<1255::aid-yea451>3.0.co;2-lDOI: 10.1002/(sici)1097-0061(19990915)15:12<1255::aid-yea451>3.0.co;2-l
Cloning and characterisation of the sagA gene of Aspergillus nidulans: a gene which affects sensitivity to DNA-damaging agents. (Journal article)
Jones, G. W., Hooley, P., Farrington, S. M., Shawcross, S. G., Iwanejko, L. A., & Strike, P. (1999). Cloning and characterisation of the sagA gene of Aspergillus nidulans: a gene which affects sensitivity to DNA-damaging agents.. Molecular & general genetics : MGG, 261(2), 251-258. doi:10.1007/s004380050964Disruption and functional analysis of six ORFs on chromosome XV: YOL117w, YOL115w ( TRF4), YOL114c, YOL112w ( MSB4), YOL111c and YOL072w. (Journal article)
Iwanejko, L., Smith, K. N., Loeillet, S., Nicolas, A., & Fabre, F. (1999). Disruption and functional analysis of six ORFs on chromosome XV: YOL117w, YOL115w ( TRF4), YOL114c, YOL112w ( MSB4), YOL111c and YOL072w.. Yeast (Chichester, England), 15(14), 1529-1539. doi:3.0.co;2-y">10.1002/(sici)1097-0061(199910)15:14<1529::aid-yea457>3.0.co;2-yDOI: 10.1002/(sici)1097-0061(199910)15:14<1529::aid-yea457>3.0.co;2-y