2024
Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6. (Journal article)
Howie, J., Tulloch, L. B., Brown, E., Reilly, L., Ashford, F. B., Kennedy, J., . . . Fuller, W. (2024). Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6.. Cell reports, 43(2), 113679. doi:10.1016/j.celrep.2024.113679DOI: 10.1016/j.celrep.2024.113679
2023
Ferguson, R., Aughton, K., Evans, A., Shaw, V., Armstrong, J., Ware, A., . . . Greenhalf, W. (2023). Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation. CURRENT ISSUES IN MOLECULAR BIOLOGY, 45(3), 2505-2520. doi:10.3390/cimb45030164DOI: 10.3390/cimb45030164
2022
Aughton, K., Sabat-Pospiech, D., Barlow, S., Coupland, S. E., & Kalirai, H. (2022). Investigating the Role of DUSP4 in Uveal Melanoma.. Translational vision science & technology, 11(12), 13. doi:10.1167/tvst.11.12.13DOI: 10.1167/tvst.11.12.13
Draper, J., Alexander, J., Nair, R. M. M., Scullion, N., Narayana, R. V. L., Aughton, K., . . . Coupland, S. E. E. (2022). Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cells on Tumor Growth and Metastasis. CURRENT EYE RESEARCH. doi:10.1080/02713683.2022.2152055DOI: 10.1080/02713683.2022.2152055
2021
Aughton, K., Elander, N. O., Evans, A., Jackson, R., Campbell, F., Costello, E., . . . Greenhalf, W. (2021). hENT1 Predicts Benefit from Gemcitabine in Pancreatic Cancer but Only with Low CDA mRNA. CANCERS, 13(22). doi:10.3390/cancers13225758DOI: 10.3390/cancers13225758
2020
MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators. (Journal article)
Aughton, K., Kalirai, H., & Coupland, S. E. (2020). MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators.. International Journal of Molecular Sciences, 21(16). doi:10.3390/ijms21165648DOI: 10.3390/ijms21165648
Thornton, S., Kalirai, H., Aughton, K., & Coupland, S. E. (2020). Unpacking the genetic etiology of uveal melanoma. Expert Review of Ophthalmology. doi:10.1080/17469899.2020.1785872DOI: 10.1080/17469899.2020.1785872
Aughton, K., Shahidipour, H., Djirackor, L., Coupland, S. E., & Kalirai, H. (2020). Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture. Translational Vision Science and Technology, 9(7). doi:10.1167/tvst.9.7.39DOI: 10.1167/tvst.9.7.39
2018
Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., . . . Canc, E. S. G. P. (2018). Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy. British Journal of Cancer, 118, 1084-1088. doi:10.1038/s41416-018-0005-1DOI: 10.1038/s41416-018-0005-1
Development of Novel Therapeutic Response Biomarkers (Chapter)
Elander, N., Aughton, K., & Greenhalf, W. (2018). Development of Novel Therapeutic Response Biomarkers. In Pancreatic Cancer (pp. 1273-1304). Springer New York. doi:10.1007/978-1-4939-7193-0_59DOI: 10.1007/978-1-4939-7193-0_59
Elander, N. O., Aughton, K., Ghaneh, P., Neoptolemos, J. P., Palmer, D. H., Cox, T. F., . . . Greenhalf, W. (2018). Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predict survival in pancreatic cancer.. British Journal of Cancer, 118(7), 947-954. doi:10.1038/s41416-018-0004-2DOI: 10.1038/s41416-018-0004-2
2015
Multiple quantum filtered <SUP>23</SUP>Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]<sub>i</sub> (Journal article)
Eykyn, T. R., Aksentijevic, D., Aughton, K. L., Southworth, R., Fuller, W., & Shattock, M. J. (2015). Multiple quantum filtered <SUP>23</SUP>Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]<sub>i</sub>. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 86, 95-101. doi:10.1016/j.yjmcc.2015.07.009DOI: 10.1016/j.yjmcc.2015.07.009
2014
Boguslavskyi, A., Pavlovic, D., Aughton, K., Clark, J. E., Howie, J., Fuller, W., & Shattock, M. J. (2014). Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman.. Cardiovascular research, 104(1), 72-82. doi:10.1093/cvr/cvu182DOI: 10.1093/cvr/cvu182
2013
Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism. (Journal article)
Pavlovic, D., Hall, A. R., Kennington, E. J., Aughton, K., Boguslavskyi, A., Fuller, W., . . . Shattock, M. J. (2013). Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism.. Journal of molecular and cellular cardiology, 61, 164-171. doi:10.1016/j.yjmcc.2013.04.013DOI: 10.1016/j.yjmcc.2013.04.013
A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle. (Journal article)
Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., . . . Fuller, W. (2013). A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle.. The Journal of biological chemistry, 288(19), 13808-13820. doi:10.1074/jbc.m113.460956DOI: 10.1074/jbc.m113.460956
2011
In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist. (Journal article)
af Forselles, K. J., Root, J., Clarke, T., Davey, D., Aughton, K., Dack, K., & Pullen, N. (2011). In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist.. British journal of pharmacology, 164(7), 1847-1856. doi:10.1111/j.1476-5381.2011.01495.xDOI: 10.1111/j.1476-5381.2011.01495.x
2008
Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro. (Journal article)
Aughton, K. L., Hamilton-Smith, K., Gupta, J., Morton, J. S., Wayman, C. P., & Jackson, V. M. (2008). Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro.. British journal of pharmacology, 155(2), 236-243. doi:10.1038/bjp.2008.253DOI: 10.1038/bjp.2008.253
2002
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma (Journal article)
Lovat, P. E., Oliverio, S., Ranalli, M., Corazzi, M., Rodolfo, C., Bernassola, F., . . . Redfern, C. P. (n.d.). GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Research.