Dr Hazel Sutherland
Research Associate Musculoskeletal & Ageing Science
- +44 (0)151 794 9062
- Work email H.Sutherland@liverpool.ac.uk
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2024
Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria. (Journal article)
Norman, B. P., Sutherland, H., Wilson, P. J. M., Rutland, D. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2024). Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria.. Journal of inherited metabolic disease. doi:10.1002/jimd.127282023
Bile is a route of excretion for homogentisic acid in alkaptonuria (Preprint)
Conserved and species-specific transcriptional responses to daily programmed resistance exercise in rat and mouse. (Journal article)
Viggars, M. R., Sutherland, H., Cardozo, C. P., & Jarvis, J. C. (2023). Conserved and species-specific transcriptional responses to daily programmed resistance exercise in rat and mouse.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37(12), e23299. doi:10.1096/fj.202301611rConserved and species-specific transcriptional responses to daily programmed resistance exercise in rat and mouse (Preprint)
Skeletal progenitor LRP1-mediated endocytosis is critical for synovial joint formation and bone growth (Preprint)
Adaptation of the transcriptional response to resistance exercise over 4 weeks of daily training (Journal article)
Viggars, M. R., Sutherland, H., Lanmueller, H., Schmoll, M., Bijak, M., & Jarvis, J. C. (2023). Adaptation of the transcriptional response to resistance exercise over 4 weeks of daily training. FASEB JOURNAL, 37(1). doi:10.1096/fj.202201418R2022
Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria (Journal article)
Norman, B. P., Davison, A. S., Hickton, B., Ross, G. A., Milan, A. M., Hughes, A. T., . . . Ranganath, L. R. (2022). Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria. METABOLITES, 12(10). doi:10.3390/metabo12100927Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism (Journal article)
Norman, B. P., Davison, A. S., Hughes, J. H., Sutherland, H., Wilson, P. J. M., Berry, N. G., . . . Gallagher, J. A. (2022). Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism. GENES & DISEASES, 9(4), 1129-1142. doi:10.1016/j.gendis.2021.02.007Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria (Journal article)
Davison, A. S., Norman, B. P., Sutherland, H., Milan, A. M., Gallagher, J. A., Jarvis, J. C., & Ranganath, L. R. (2022). Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria. METABOLITES, 12(6). doi:10.3390/metabo12060477Altered bone metabolism in the rare inherited disease alkaptonuria (Conference Paper)
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A3). Retrieved from https://www.webofscience.com/Altered bone metabolism in the rare inherited disease alkaptonuria (Conference Paper)
Norman, B. P., Hughes, J. H., Sutherland, H., Wilson, P. J., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2022). Altered bone metabolism in the rare inherited disease alkaptonuria. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 103 (pp. A8-A9). Retrieved from https://www.webofscience.com/2021
Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces (Journal article)
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Wilson, P. J. M., Ranganath, L. R., . . . Gallagher, J. A. (n.d.). Anatomical Distribution of Ochronotic Pigment in Alkaptonuric Mice is Associated with Calcified Cartilage Chondrocytes at Osteochondral Interfaces. Calcified Tissue International. doi:10.1007/s00223-020-00764-6The anatomical distribution of ochronotic pigment in alkaptonuric mice reveals that ageing and mechanical loading make collagen susceptible to chemical attack (Conference Paper)
Hughes, J. H., Keenan, C. M., Sutherland, H., Edwards, H. R., Ranganath, L. R., Bou-Gharios, G., & Gallagher, J. A. (2021). The anatomical distribution of ochronotic pigment in alkaptonuric mice reveals that ageing and mechanical loading make collagen susceptible to chemical attack. In JOURNAL OF ANATOMY Vol. 238 (pp. 200). Retrieved from https://www.webofscience.com/2020
Nitisinone causes acquired tyrosinosis in alkaptonuria (Journal article)
Khedr, M., Cooper, M. S., Hughes, A. T., Milan, A. M., Davison, A. S., Norman, B. P., . . . Ranganath, L. R. (2020). Nitisinone causes acquired tyrosinosis in alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(5), 1014-1023. doi:10.1002/jimd.12229Adaptation of rat fast-twitch muscle to endurance activity is underpinned by changes to protein degradation as well as protein synthesis (Journal article)
Hesketh, S. J., Sutherland, H., Lisboa, P. J., Jarvis, J. C., & Burniston, J. G. (2020). Adaptation of rat fast-twitch muscle to endurance activity is underpinned by changes to protein degradation as well as protein synthesis. FASEB JOURNAL, 34(8), 10398-10417. doi:10.1096/fj.202000668RRFractional Synthesis Rates of Individual Proteins in Rat Soleus and Plantaris Muscles (Journal article)
Stead, C. A., Hesketh, S. J., Bennett, S., Sutherland, H., Jarvis, J. C., Lisboa, P. J., & Burniston, J. G. (2020). Fractional Synthesis Rates of Individual Proteins in Rat Soleus and Plantaris Muscles. PROTEOMES, 8(2). doi:10.3390/proteomes8020010Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria (Journal article)
Hughes, J. H., Wilson, P. J. M., Sutherland, H., Judd, S., Hughes, A. T., Milan, A. M., . . . Gallagher, J. A. (2020). Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43(2), 259-268. doi:10.1002/jimd.121722019
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria (Journal article)
Hughes, J. H., Liu, K., Plagge, A., Wilson, P. J. M., Sutherland, H., Norman, B. P., . . . Bou-Gharios, G. (2019). Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human Molecular Genetics, 28(23), 3928-3939. doi:10.1093/hmg/ddz234Concentric lamellae - novel microanatomical structures in the articular calcified cartilage of mice (Journal article)
Keenan, C. M., Beckett, A. J., Sutherland, H., Ranganath, L. R., Jarvis, J. C., Prior, I. A., & Gallagher, J. A. (2019). Concentric lamellae - novel microanatomical structures in the articular calcified cartilage of mice. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-47545-2UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy (Journal article)
Seaborne, R. A., Hughee, D. C., Turner, D. C., Owens, D. J., Baehr, L. M., Gorski, P., . . . Sharples, A. P. (2019). UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy. JOURNAL OF PHYSIOLOGY-LONDON, 597(14), 3727-3749. doi:10.1113/JP278073Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging. (Journal article)
Davison, A. S., Strittmatter, N., Sutherland, H., Hughes, A. T., Hughes, J., Bou-Gharios, G., . . . Gallagher, J. A. (2019). Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.. Metabolomics : Official journal of the Metabolomic Society, 15(5), 68. doi:10.1007/s11306-019-1531-4UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy (Preprint)
A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria. (Journal article)
Norman, B. P., Davison, A. S., Ross, G. A., Milan, A. M., Hughes, A. T., Sutherland, H., . . . Ranganath, L. R. (2019). A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.. Clinical chemistry. doi:10.1373/clinchem.2018.2953452018
SpillOver stimulation: A novel hypertrophy model using co-contraction of the plantar-flexors to load the tibial anterior muscle in rats (Journal article)
Schmoll, M., Unger, E., Sutherland, H., Haller, M., Bijak, M., Lanmueller, H., & Jarvis, J. C. (2018). SpillOver stimulation: A novel hypertrophy model using co-contraction of the plantar-flexors to load the tibial anterior muscle in rats. PLOS ONE, 13(11). doi:10.1371/journal.pone.0207886DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (Conference Paper)
Norman, B. P., Ying, C. W., Sutherland, H., Wilson, P. J., Roberts, N. B., Duer, M. J., . . . Gallagher, J. A. (2018). DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S99). doi:10.1016/j.joca.2018.02.214GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA (Conference Paper)
Hughes, J. H., Liu, K., Sutherland, H., Wilson, P. J., Hughes, A. T., Milan, A. M., . . . Bou-Gharios, G. (2018). GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S89-S90). doi:10.1016/j.joca.2018.02.1942017
In-situ measurements of tensile forces in the tibialis anterior tendon of the rat in concentric, isometric, and resisted co-contractions (Journal article)
Schmoll, M., Unger, E., Sutherland, H., Haller, M., Bijak, M., Lanmueller, H., & Jarvis, J. C. (2017). In-situ measurements of tensile forces in the tibialis anterior tendon of the rat in concentric, isometric, and resisted co-contractions. PHYSIOLOGICAL REPORTS, 5(8). doi:10.14814/phy2.132452016
On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat (Journal article)
Hesketh, S., Srisawat, K., Sutherland, H., Jarvis, J., & Burniston, J. (2016). On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat. PROTEOMES, 4(1). doi:10.3390/proteomes40100122015
Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice (Journal article)
Keenan, C. M., Preston, A. J., Sutherland, H., Wilson, P. J., Psarelli, E. E., Cox, T. F., . . . Gallagher, J. A. (2015). Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice. JIMD REPORTS, VOL 24, 24, 45-50. doi:10.1007/8904_2015_4372014
Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle (Journal article)
Vickerton, P., Jarvis, J. C., Gallagher, J. A., Akhtar, R., Sunderland, H., & Jeffery, N. (2014). Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle. Proceedings of the Royal Society B: Biological Sciences, 281(1788). doi:10.1098/rspb.2014.0786192. Development of Osteoarthritis in Alkaptonuric Mice (Journal article)
Keenan, C. M., Sutherland, H., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). 192. Development of Osteoarthritis in Alkaptonuric Mice. Rheumatology, 53(suppl_1), i131. doi:10.1093/rheumatology/keu111.001IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE (Conference Paper)
Keenan, C. M., Beckett, A., Sutherland, H., Prior, I., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S363-S364). doi:10.1016/j.joca.2014.02.673DEVELOPMENT OF OSTEOARTHRITIS IN ALKAPTONURIC MICE (Conference Paper)
Keenan, C. M., Sutherland, H., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). DEVELOPMENT OF OSTEOARTHRITIS IN ALKAPTONURIC MICE. In RHEUMATOLOGY Vol. 53 (pp. 131). Retrieved from https://www.webofscience.com/Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone (Journal article)
Preston, A. J., Keenan, C. M., Sutherland, H., Wilson, P. J., Wlodarski, B., Taylor, A. M., . . . Jarvis, J. C. (2014). Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone. ANNALS OF THE RHEUMATIC DISEASES, 73(1), 284-289. doi:10.1136/annrheumdis-2012-2028782013
Initiation and progression of ochronotic osteoarthropathy in alkaptonuric mice (Journal article)
Keenan, C. M., Preston, A. J., Sutherland, H., Taylor, A. M., Wilson, P. J., Williams, D., . . . Jarvis, J. C. (2013). Initiation and progression of ochronotic osteoarthropathy in alkaptonuric mice. Osteoarthritis and Cartilage, 21, S70-S71. doi:10.1016/j.joca.2013.02.1552012
Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition (Journal article)
Taylor, A. M., Preston, A. J., Paulk, N. K., Sutherland, H., Keenan, C. M., Wilson, P. J. M., . . . Jarvis, J. C. (2012). Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition. OSTEOARTHRITIS AND CARTILAGE, 20(8), 880-886. doi:10.1016/j.joca.2012.04.0132010
Can you make a sphincter out of skeletal muscle? (Journal article)
Salmons, S., Russold, M., Ramnarine, I., Ashley, Z., Sutherland, H., & Jarvis, J. (2010). Can you make a sphincter out of skeletal muscle?. Physiology News, (Summer 2010), 23-25. doi:10.36866/pn.79.23Practical and effective stomal sphincter creation: evaluation in pigs. (Journal article)
Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: evaluation in pigs.. Diseases of the colon and rectum, 53(4), 467-474. doi:10.1007/dcr.0b013e3181bdbe912008
Therapeutic stimulation of denervated muscles: the influence of pattern. (Journal article)
Ashley, Z., Sutherland, H., Russold, M. F., Lanmüller, H., Mayr, W., Jarvis, J. C., & Salmons, S. (2008). Therapeutic stimulation of denervated muscles: the influence of pattern.. Muscle & nerve, 38(1), 875-886. doi:10.1002/mus.210202007
Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb. (Journal article)
Ashley, Z., Salmons, S., Boncompagni, S., Protasi, F., Russold, M., Lanmuller, H., . . . Jarvis, J. C. (2007). Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb.. Journal of muscle research and cell motility, 28(4-5), 203-217. doi:10.1007/s10974-007-9119-4Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year. (Journal article)
Ashley, Z., Sutherland, H., Lanmüller, H., Russold, M. F., Unger, E., Bijak, M., . . . Jarvis, J. C. (2007). Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year.. American journal of physiology. Cell physiology, 292(1), C440-C451. doi:10.1152/ajpcell.00085.20062006
Adaptive conditioning of skeletal muscle in a large animal model (Sus domesticus). (Journal article)
Sutherland, H., Salmons, S., Ramnarine, I. R., Capoccia, M., Walsh, A. A., & Jarvis, J. C. (2006). Adaptive conditioning of skeletal muscle in a large animal model (Sus domesticus).. Journal of anatomy, 209(2), 165-177. doi:10.1111/j.1469-7580.2006.00598.xCounterpulsation from the skeletal muscle ventricle and the intraaortic balloon pump in the normal and failing circulations. (Journal article)
Ramnarine, I. R., Capoccia, M., Ashley, Z., Sutherland, H., Russold, M., Summerfield, N., . . . Jarvis, J. C. (2006). Counterpulsation from the skeletal muscle ventricle and the intraaortic balloon pump in the normal and failing circulations.. Circulation, 114(1 Suppl), I10-I15. doi:10.1161/circulationaha.105.0003722005
Implantable device for long-term electrical stimulation of denervated muscles in rabbits. (Journal article)
Lanmüller, H., Ashley, Z., Unger, E., Sutherland, H., Reichel, M., Russold, M., . . . Salmons, S. (2005). Implantable device for long-term electrical stimulation of denervated muscles in rabbits.. Medical & biological engineering & computing, 43(4), 535-540. doi:10.1007/bf02344737Determination of the chronaxie and rheobase of denervated limb muscles in conscious rabbits. (Journal article)
Ashley, Z., Sutherland, H., Lanmuller, H., Unger, E., Li, F., Mayr, W., . . . Salmons, S. (2005). Determination of the chronaxie and rheobase of denervated limb muscles in conscious rabbits.. Artificial organs, 29(3), 212-215. doi:10.1111/j.1525-1594.2005.29037.xFunctional electrical stimulation of denervated muscles: basic issues. (Journal article)
Salmons, S., Ashley, Z., Sutherland, H., Russold, M. F., Li, F., & Jarvis, J. C. (2005). Functional electrical stimulation of denervated muscles: basic issues.. Artificial organs, 29(3), 199-202. doi:10.1111/j.1525-1594.2005.29034.x2004
A nonradioactive assay for nitric oxide synthase activity in tissue extracts. (Journal article)
Sutherland, H., Zolle, O., Khundkar, R., Simpson, A. W. M., Jarvis, J. C., & Salmons, S. (2004). A nonradioactive assay for nitric oxide synthase activity in tissue extracts.. Methods in molecular biology (Clifton, N.J.), 279, 105-111. doi:10.1385/1-59259-807-2:1052003
Pattern dependence in the stimulation-induced type transformation of rabbit fast skeletal muscle. (Journal article)
Sutherland, H., Jarvis, J. C., & Salmons, S. (2003). Pattern dependence in the stimulation-induced type transformation of rabbit fast skeletal muscle.. Neuromodulation : journal of the International Neuromodulation Society, 6(3), 176-189. doi:10.1046/j.1525-1403.2003.03025.x2002
The hemodynamic function of intrathoracic skeletal muscle ventricles after recovery from surgery in pigs. (Journal article)
Capoccia, M., Sutherland, H., Salmons, S., & Jarvis, J. C. (2002). The hemodynamic function of intrathoracic skeletal muscle ventricles after recovery from surgery in pigs.. Artificial organs, 26(3), 235-237. doi:10.1046/j.1525-1594.2002.06940.x2001
Induction of a fatigue-resistant phenotype in rabbit fast muscle by small daily amounts of stimulation. (Journal article)
Lopez-Guajardo, A., Sutherland, H., Jarvis, J. C., & Salmons, S. (2001). Induction of a fatigue-resistant phenotype in rabbit fast muscle by small daily amounts of stimulation.. Journal of applied physiology (Bethesda, Md. : 1985), 90(5), 1909-1918. doi:10.1152/jappl.2001.90.5.1909A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle. (Journal article)
Sutherland, H., Khundkar, R., Zolle, O., McArdle, A., Simpson, A. W., Jarvis, J. C., & Salmons, S. (2001). A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle.. Nitric oxide : biology and chemistry, 5(5), 475-481. doi:10.1006/niox.2001.03742000
Dynamics of stimulation-induced muscle adaptation: insights from varying the duty cycle. (Journal article)
Lopez-Guajardo, A., Sutherland, H., Jarvis, J. C., & Salmons, S. (2000). Dynamics of stimulation-induced muscle adaptation: insights from varying the duty cycle.. Journal of muscle research and cell motility, 21(8), 725-735. doi:10.1023/a:10103535150041998
The dose-related response of rabbit fast muscle to long-term low-frequency stimulation. (Journal article)
Sutherland, H., Jarvis, J. C., Kwende, M. M., Gilroy, S. J., & Salmons, S. (1998). The dose-related response of rabbit fast muscle to long-term low-frequency stimulation.. Muscle & nerve, 21(12), 1632-1646. doi:3.0.co;2-w">10.1002/(sici)1097-4598(199812)21:12<1632::aid-mus3>3.0.co;2-wDOI: 10.1002/(sici)1097-4598(199812)21:12<1632::aid-mus3>3.0.co;2-w
1996
Fast-to-slow transformation in stimulated rat muscle. (Journal article)
Jarvis, J. C., Mokrusch, T., Kwende, M. M., Sutherland, H., & Salmons, S. (1996). Fast-to-slow transformation in stimulated rat muscle.. Muscle & nerve, 19(11), 1469-1475. doi:3.0.co;2-o">10.1002/(sici)1097-4598(199611)19:11<1469::aid-mus11>3.0.co;2-oDOI: 10.1002/(sici)1097-4598(199611)19:11<1469::aid-mus11>3.0.co;2-o