2024
Haas, A. J., Karakus, M., Zihni, C., Balda, M. S., & Matter, K. (2024). ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network.. Cells, 13(7), 640. doi:10.3390/cells13070640DOI: 10.3390/cells13070640
2023
ZO-1 regulates Hippo-independent YAP activity and cell proliferation via a GEF-H1- and TBK1-regulated mechanosensitive signalling network (Preprint)
DOI: 10.1101/2023.12.04.569957
2022
ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions (Journal article)
Haas, A. J. J., Zihni, C., Krug, S. M. M., Maraspini, R., Otani, T., Furuse, M., . . . Matter, K. (2022). ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions. CELLS, 11(23). doi:10.3390/cells11233775DOI: 10.3390/cells11233775
Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis (Journal article)
Zihni, C., Georgiadis, A., Ramsden, C. M., Sanchez-Heras, E., Haas, A. J., Nommiste, B., . . . Matter, K. (2022). Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis. JOURNAL OF CELL BIOLOGY, 221(11). doi:10.1083/jcb.202012042DOI: 10.1083/jcb.202012042
Reciprocal regulation between cell mechanics and ZO-1 guides tight junction assembly and epithelial morphogenesis (Preprint)
DOI: 10.1101/2022.07.17.500023
2021
MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block? (Journal article)
Zihni, C. (2021). MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block?. TISSUE BARRIERS, 9(3). doi:10.1080/21688370.2021.1916380DOI: 10.1080/21688370.2021.1916380
A Gene Therapy Technology to Treat Retinal Disease (Patent)
Zihni, C., Matter, K., & Balda, M. (2021, February 2). US20230135501A1, A Gene Therapy Technology to Treat Retinal Disease. Worldwide.
2020
Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly (Journal article)
Haas, A. J., Zihni, C., Ruppel, A., Hartmann, C., Ebnet, K., Tada, M., . . . Matter, K. (2020). Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly. CELL REPORTS, 32(3). doi:10.1016/j.celrep.2020.107924DOI: 10.1016/j.celrep.2020.107924
2018
An Imaging Protocol to Quantitate Microvilli Ultrastructure Induction by Epithelia. (Journal article)
Zihni, C., Zihni, C., S Balda, M., & Matter, K. (n.d.). An Imaging Protocol to Quantitate Microvilli Ultrastructure Induction by Epithelia.. Protocol Exchange. doi:10.1038/protex.2017.112DOI: 10.1038/protex.2017.112
2017
An apical MRCK-driven morphogenetic pathway controls epithelial polarity (Journal article)
Zihni, C., Vlassaks, E., Terry, S., Carlton, J., Leung, T. K. C., Olson, M., . . . Matter, K. (2017). An apical MRCK-driven morphogenetic pathway controls epithelial polarity. NATURE CELL BIOLOGY, 19(9), 1049-+. doi:10.1038/ncb3592DOI: 10.1038/ncb3592
Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration (Journal article)
Arno, G., Carss, K. J., Hull, S., Zihni, C., Robson, A. G., Fiorentino, A., . . . Webster, A. R. (2017). Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. AMERICAN JOURNAL OF HUMAN GENETICS, 100(2), 334-342. doi:10.1016/j.ajhg.2016.12.014DOI: 10.1016/j.ajhg.2016.12.014
2016
Tight junctions: from simple barriers to multifunctional molecular gates (Journal article)
Zihni, C., Mills, C., Matter, K., & Balda, M. S. (2016). Tight junctions: from simple barriers to multifunctional molecular gates. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 17(9), 564-580. doi:10.1038/nrm.2016.80DOI: 10.1038/nrm.2016.80
2015
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer (Journal article)
Zihni, C., & Terry, S. J. (2015). RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 64, 120-125. doi:10.1016/j.biocel.2015.02.020DOI: 10.1016/j.biocel.2015.02.020
2014
Signalling at tight junctions during epithelial differentiation and microbial pathogenesis (Journal article)
Zihni, C., Balda, M. S., & Matter, K. (2014). Signalling at tight junctions during epithelial differentiation and microbial pathogenesis. JOURNAL OF CELL SCIENCE, 127(16), 3401-3413. doi:10.1242/jcs.145029DOI: 10.1242/jcs.145029
MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival (Journal article)
Steed, E., Elbediwy, A., Vacca, B., Dupasquier, S., Hemkemeyer, S. A., Suddason, T., . . . Matter, K. (2014). MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. JOURNAL OF CELL BIOLOGY, 204(5), 821-838. doi:10.1083/jcb.201304115DOI: 10.1083/jcb.201304115
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation (Journal article)
Zihni, C., Munro, P. M. G., Elbediwy, A., Keep, N. H., Terry, S. J., Harris, J., . . . Matter, K. (2014). Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. JOURNAL OF CELL BIOLOGY, 204(1), 111-127. doi:10.1083/jcb.201304064DOI: 10.1083/jcb.201304064
2012
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex (Journal article)
Elbediwy, A., Zihni, C., Terry, S. J., Clark, P., Matter, K., & Balda, M. S. (2012). Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. JOURNAL OF CELL BIOLOGY, 198(4), 677-693. doi:10.1083/jcb.201202094DOI: 10.1083/jcb.201202094
Stimulation of Cortical Myosin Phosphorylation by p114RhoGEF Drives Cell Migration and Tumor Cell Invasion (Journal article)
Terry, S. J., Elbediwy, A., Zihni, C., Harris, A. R., Bailly, M., Charras, G. T., . . . Matter, K. (2012). Stimulation of Cortical Myosin Phosphorylation by p114RhoGEF Drives Cell Migration and Tumor Cell Invasion. PLOS ONE, 7(11). doi:10.1371/journal.pone.0050188DOI: 10.1371/journal.pone.0050188
2011
Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis (Journal article)
Terry, S. J., Zihni, C., Elbediwy, A., Vitiello, E., San, I. V. L. C., Balda, M. S., & Matter, K. (2011). Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. NATURE CELL BIOLOGY, 13(2), 159-U120. doi:10.1038/ncb2156DOI: 10.1038/ncb2156
