2024
Ainsworth, S. (2024). Noma finally recognised as a neglected tropical disease.. PLoS neglected tropical diseases, 18(5), e0012177. doi:10.1371/journal.pntd.0012177DOI: 10.1371/journal.pntd.0012177
Marriott, A. E., Casewell, N. R., Lilley, E., Gutiérrez, J. -M., & Ainsworth, S. (2024). Improving <i>in vivo</i> assays in snake venom and antivenom research: A community discussion.. F1000Research, 13, 192. doi:10.12688/f1000research.148223.1DOI: 10.12688/f1000research.148223.1
Solano, G., Cunningham, S., Edge, R. J., Duran, G., Sanchez, A., Villalta, M., . . . Ainsworth, S. (2024). African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.. BMJ global health, 9(3), e014813. doi:10.1136/bmjgh-2023-014813DOI: 10.1136/bmjgh-2023-014813
Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins. (Journal article)
Khalek, I. S., Senji Laxme, R. R., Nguyen, Y. T. K., Khochare, S., Patel, R. N., Woehl, J., . . . Jardine, J. G. (2024). Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins.. Science translational medicine, 16(735), eadk1867. doi:10.1126/scitranslmed.adk1867DOI: 10.1126/scitranslmed.adk1867
Marriott, A., Casewell, N., Lilley, E., Gutiérrez, J. -M., & Ainsworth, S. (2024). Improving in vivo assays in snake venom and antivenom research: A community discussion. doi:10.12688/f1000research.148223.1DOI: 10.12688/f1000research.148223.1
2022
Menzies, S. K., Dawson, C. A., Crittenden, E., Edge, R. J., Hall, S. R., Alsolaiss, J., . . . Ainsworth, S. (2022). Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-13376-xDOI: 10.1038/s41598-022-13376-x
Alomran, N., Blundell, P., Alsolaiss, J., Crittenden, E., Ainsworth, S., Dawson, C. A., . . . Casewell, N. R. (2022). Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms. TOXINS, 14(7). doi:10.3390/toxins14070443DOI: 10.3390/toxins14070443
Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms (Preprint)
DOI: 10.1101/2022.05.07.491032
2021
Welcome to online-only production of <i>Parasitology</i> and future-proofing of the journal's academic standards (Journal article)
Stothard, J. R., Ainsworth, S., & Marriott, A. E. (2021). Welcome to online-only production of <i>Parasitology</i> and future-proofing of the journal's academic standards. PARASITOLOGY, 148(13), 1529-1531. doi:10.1017/S003118202100144XDOI: 10.1017/S003118202100144X
Virus-like particles displaying conserved toxin epitopes stimulate broadly reactive, polyspecific, murine antibody responses capable of snake venom recognition (Preprint)
DOI: 10.21203/rs.3.rs-1044937/v1
Alomran, N., Alsolaiss, J., Albulescu, L. -O., Crittenden, E., Harrison, R. A., Ainsworth, S., & Casewell, N. R. (2021). Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.. PLoS neglected tropical diseases, 15(8), e0009659. doi:10.1371/journal.pntd.0009659DOI: 10.1371/journal.pntd.0009659
Rügen, N., Jenkins, T. P., Wielsch, N., Vogel, H., Hempel, B. -F., Süssmuth, R. D., . . . Tonk, M. (2021). Hexapod Assassins' Potion: Venom Composition and Bioactivity from the Eurasian Assassin Bug <i>Rhynocoris iracundus</i>.. Biomedicines, 9(7), 819. doi:10.3390/biomedicines9070819DOI: 10.3390/biomedicines9070819
Staton, G. J., Clegg, S. R., Ainsworth, S., Armstrong, S., Carter, S. D., Radford, A. D., . . . Evans, N. J. (2021). Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms. PLOS PATHOGENS, 17(3). doi:10.1371/journal.ppat.1009464DOI: 10.1371/journal.ppat.1009464
Kadam, P., Ainsworth, S., Sirur, F. M., Patel, D. C., Kuruvilla, J. J., & Majumdar, D. B. (2021). Approaches for implementing society-led community interventions to mitigate snakebite envenoming burden: The SHE-India experience.. PLoS neglected tropical diseases, 15(2), e0009078. doi:10.1371/journal.pntd.0009078DOI: 10.1371/journal.pntd.0009078
Convergent evolution of pain-inducing defensive venom components in spitting cobras (Journal article)
Kazandjian, T. D., Petras, D., Robinson, S. D., van Thiel, J., Greene, H. W., Arbuckle, K., . . . Casewell, N. R. (2021). Convergent evolution of pain-inducing defensive venom components in spitting cobras. SCIENCE, 371(6527), 386-+. doi:10.1126/science.abb9303DOI: 10.1126/science.abb9303
Animal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19 (Journal article)
Ainsworth, S., Menzies, S., & Pleass, R. (2020). Animal derived antibodies should be considered alongside convalescent human plasma to deliver treatments for COVID-19. doi:10.12688/wellcomeopenres.15990.1DOI: 10.12688/wellcomeopenres.15990.1
2020
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite (Journal article)
Albulescu, L. -O., Xie, C., Ainsworth, S., Alsolaiss, J., Crittenden, E., Dawson, C. A., . . . Casewell, N. R. (2020). A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-19981-6DOI: 10.1038/s41467-020-19981-6
Walsh, T. R., Ainsworth, S., Armstrong, S., Hodgkinson, J., & Williams, D. (2020). Differences in the antibody response to adult Fasciola hepatica excretory/secretory products in experimentally and naturally infected cattle and sheep. Veterinary Parasitology, 109321. doi:10.1016/j.vetpar.2020.109321DOI: 10.1016/j.vetpar.2020.109321
Ainsworth, S., Menzies, S. K., Casewell, N. R., & Harrison, R. A. (2020). An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management.. PLoS neglected tropical diseases, 14(8), e0008579. doi:10.1371/journal.pntd.0008579DOI: 10.1371/journal.pntd.0008579
A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite (Preprint)
DOI: 10.1101/2020.05.13.094599
Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite (Journal article)
Albulescu, L. -O., Hale, M. S., Ainsworth, S., Alsolaiss, J., Crittenden, E., Calvete, J. J., . . . Casewell, N. R. (2020). Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite. SCIENCE TRANSLATIONAL MEDICINE, 12(542). doi:10.1126/scitranslmed.aay8314DOI: 10.1126/scitranslmed.aay8314
Snake Venom Gland Organoids (Journal article)
Post, Y., Puschhof, J., Beumer, J., Kerkkamp, H. M., de Bakker, M. A. G., Slagboom, J., . . . Clevers, H. (2020). Snake Venom Gland Organoids. CELL, 180(2), 233-+. doi:10.1016/j.cell.2019.11.038DOI: 10.1016/j.cell.2019.11.038
2019
The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims (Journal article)
Harrison, R. A., Casewell, N. R., Ainsworth, S. A., & Lalloo, D. G. (2019). The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 113(12), 834-837. doi:10.1093/trstmh/try134DOI: 10.1093/trstmh/try134
Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite (Preprint)
DOI: 10.1101/717280
Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming (Journal article)
Williams, D. J., Abul Faiz, M., Abela-Ridder, B., Ainsworth, S., Bulfone, T. C., Nickerson, A. D., . . . Warrell, D. A. (2019). Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming. PLOS NEGLECTED TROPICAL DISEASES, 13(2). doi:10.1371/journal.pntd.0007059DOI: 10.1371/journal.pntd.0007059
A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite (Journal article)
Albulescu, L. -O., Kazandjian, T., Slagboom, J., Bruyneel, B., Ainsworth, S., Alsolaiss, J., . . . Casewell, N. R. (2019). A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite. FRONTIERS IN PHARMACOLOGY, 10. doi:10.3389/fphar.2019.00848DOI: 10.3389/fphar.2019.00848
2018
Ainsworth, S., Slagboom, J., Alomran, N., Pla, D., Alhamdi, Y., King, S. I., . . . Casewell, N. R. (2018). The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms. COMMUNICATIONS BIOLOGY, 1. doi:10.1038/s42003-018-0039-1DOI: 10.1038/s42003-018-0039-1
Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins. (Journal article)
Vanzolini, K. L., Ainsworth, S., Bruyneel, B., Herzig, V., Seraus, M. G. L., Somsen, G. W., . . . Kool, J. (2018). Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.. Toxicon : official journal of the International Society on Toxinology, 152, 1-8. doi:10.1016/j.toxicon.2018.06.080DOI: 10.1016/j.toxicon.2018.06.080
The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms. (Journal article)
Ainsworth, S., Petras, D., Engmark, M., Süssmuth, R. D., Whiteley, G., Albulescu, L. -O., . . . Calvete, J. J. (2018). The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.. Journal of proteomics, 172, 173-189. doi:10.1016/j.jprot.2017.08.016DOI: 10.1016/j.jprot.2017.08.016
2017
Harrison, R. A., Oluoch, G. O., Ainsworth, S., Alsolaiss, J., Bolton, F., Arias, A. -S., . . . Casewell, N. R. (2017). Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.. PLoS neglected tropical diseases, 11(10), e0005969. doi:10.1371/journal.pntd.0005969DOI: 10.1371/journal.pntd.0005969
Sadovskaya, I., Vinogradov, E., Courtin, P., Armalyte, J., Meyrand, M., Giaouris, E., . . . Chapot-Chartier, M. -P. (2017). Another Brick in the Wall: a Rhamnan Polysaccharide Trapped inside Peptidoglycan of <i>Lactococcus lactis</i>.. mBio, 8(5), e01303-e01317. doi:10.1128/mbio.01303-17DOI: 10.1128/mbio.01303-17
2016
Isolation of digital dermatitis treponemes from cattle hock skin lesions (Journal article)
Clegg, S. R., Bell, J., Ainsworth, S., Blowey, R. W., Bell, N. J., Carter, S. D., & Evans, N. J. (2016). Isolation of digital dermatitis treponemes from cattle hock skin lesions. VETERINARY DERMATOLOGY, 27(2), 106-E30. doi:10.1111/vde.12286DOI: 10.1111/vde.12286
2015
Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the <i>plasminogen</i> (<i>PLG</i>) gene (Journal article)
Ainsworth, S., Carter, S., Fisher, C., Dawson, J., Makrides, L., Nuttall, T., & Mason, S. L. (2015). Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the <i>plasminogen</i> (<i>PLG</i>) gene. ANIMAL GENETICS, 46(6), 707-710. doi:10.1111/age.12339DOI: 10.1111/age.12339
2014
The Lactococcus lactis plasmidome: much learnt, yet still lots to discover. (Journal article)
Ainsworth, S., Stockdale, S., Bottacini, F., Mahony, J., & van Sinderen, D. (2014). The Lactococcus lactis plasmidome: much learnt, yet still lots to discover.. FEMS microbiology reviews, 38(5), 1066-1088. doi:10.1111/1574-6976.12074DOI: 10.1111/1574-6976.12074
Ainsworth, S., Mahony, J., & van Sinderen, D. (2014). The plasmid complement of Lactococcus lactis UC509.9 encodes multiple bacteriophage resistance systems.. Applied and environmental microbiology, 80(14), 4341-4349. doi:10.1128/aem.01070-14DOI: 10.1128/aem.01070-14
Ainsworth, S., Sadovskaya, I., Vinogradov, E., Courtin, P., Guerardel, Y., Mahony, J., . . . van Sinderen, D. (2014). Differences in lactococcal cell wall polysaccharide structure are major determining factors in bacteriophage sensitivity.. mBio, 5(3), e00880-e00814. doi:10.1128/mbio.00880-14DOI: 10.1128/mbio.00880-14
2013
Murphy, J., Mahony, J., Ainsworth, S., Nauta, A., & van Sinderen, D. (2013). Bacteriophage orphan DNA methyltransferases: insights from their bacterial origin, function, and occurrence.. Applied and environmental microbiology, 79(24), 7547-7555. doi:10.1128/aem.02229-13DOI: 10.1128/aem.02229-13
Ainsworth, S., Zomer, A., Mahony, J., & van Sinderen, D. (2013). Lytic infection of Lactococcus lactis by bacteriophages Tuc2009 and c2 triggers alternative transcriptional host responses.. Applied and environmental microbiology, 79(16), 4786-4798. doi:10.1128/aem.01197-13DOI: 10.1128/aem.01197-13
Mahony, J., Kot, W., Murphy, J., Ainsworth, S., Neve, H., Hansen, L. H., . . . van Sinderen, D. (2013). Investigation of the relationship between lactococcal host cell wall polysaccharide genotype and 936 phage receptor binding protein phylogeny.. Applied and environmental microbiology, 79(14), 4385-4392. doi:10.1128/aem.00653-13DOI: 10.1128/aem.00653-13
Ainsworth, S., Zomer, A., de Jager, V., Bottacini, F., van Hijum, S. A. F. T., Mahony, J., & van Sinderen, D. (2013). Complete Genome of Lactococcus lactis subsp. cremoris UC509.9, Host for a Model Lactococcal P335 Bacteriophage.. Genome announcements, 1(1), e00119-e00112. doi:10.1128/genomea.00119-12DOI: 10.1128/genomea.00119-12
2012
Phages of lactic acid bacteria: the role of genetics in understanding phage-host interactions and their co-evolutionary processes. (Journal article)
Mahony, J., Ainsworth, S., Stockdale, S., & van Sinderen, D. (2012). Phages of lactic acid bacteria: the role of genetics in understanding phage-host interactions and their co-evolutionary processes.. Virology, 434(2), 143-150. doi:10.1016/j.virol.2012.10.008DOI: 10.1016/j.virol.2012.10.008