Current projects
We have developed a variety of clinically relevant models of respiratory, mucosal and systemic infection with bacteria such as Streptococcus pneumoniae, S. agalactiae, S. pyogenes and Pseudomonas aeruginosa, and viruses such as RSV, IAV and SARS-CoV-2, covering conditions such as nasopharyngeal carriage, chronic and invasive pneumonia, meningitis and sepsis as well as biofilm related respiratory tract infections (Pseudomonas). These models are applied to understand host-pathogen interactions on a holistic level, but also to test potential vaccine candidates and novel therapeutics.