Biochemistry - Endocytosis in cell and tissue homeostasis

Supervisor: Dr Kazuhiro Yamamoto

Supervisor bio: I am a biochemist with a primary interest in the regulation of extracellular matrix turnover: how molecules surrounding the cells are degraded or accumulated in pathophysiological processes. Recently, I was awarded the Versus Arthritis Bridging Fellowship to pursue fundamental research aiming to understand the molecular mechanisms that keep healthy cellular environments in adult tissues.

Email: kazuhiro.yamamoto@liverpool.ac.uk

School: Life Sciences

Department: Biochemistry

Module code: LIFE398

Suitable for students of: N/A

Desirable experience/requirements: N/A

Places available: 2

Start dates: 10 June 2024, 1 July 2024

Project length: 8-12 weeks 

Virtual option: No

Project description: 

Endocytosis is the process by which cells control the composition of their cell surface and extracellular environment and is thus essential for cellular signalling and metabolism. Cells constantly internalise large amounts of molecules from the cell surface and microenvironment, storing them inside the cell, recycling them back to the extracellular milieu, or degrading them in lysosomes. Our research focuses on the molecular mechanisms that keep healthy cellular environments in adult tissues. The student will investigate what type of molecules are internalised by the cells, and how it affects cellular behaviours and pathological conditions where the endocytic regulation is disrupted. The study will use biochemical, molecular, cell biological and imaging techniques.

Additional requirements: N/A