Ecophysiology of Bacterial Lipid Remodelling
1:00pm - 2:00pm /
Monday 4th March 2019
/ Venue: Lecture Theatre 1 Life Sciences Building
- Luning Liu
- Suitable for: Staff and students with an interest in Genomes, Systems and Therapeutic Targeting
- Admission: Free
Add this event to my calendar
Click on "Create a calendar file" and your browser will download a .ics file for this event.
Microsoft Outlook: Download the file, double-click it to open it in Outlook, then click on "Save & Close" to save it to your calendar. If that doesn't work go into Outlook, click on the File tab, then on Open & Export, then Open Calendar. Select your .ics file then click on "Save & Close".
Google Calendar: download the file, then go into your calendar. On the left where it says "Other calendars" click on the arrow icon and then click on Import calendar. Click on Browse and select the .ics file, then click on Import.
Apple Calendar: The file may open automatically with an option to save it to your calendar. If not, download the file, then you can either drag it to Calendar or import the file by going to File >Import > Import and choosing the .ics file.
Speaker: Yin Chen
Membrane lipids form the structural basis of all cells. In bacteria Escherichia coli uses predominantly phosphorus-containing phospholipids in its cell envelope, including phosphatidylethanolamine and phosphatidylglycerol. However, beyond E. coli a range of lipids are found in bacterial membranes, including phospholipids as well as phosphorus (P)-free lipids such as betaine lipids, ornithine lipids, sulfolipids and glycolipids. It is well established that P availability significantly affects lipid composition in bacteria, whereby non-P sulfur-containing lipids are used to substitute phospholipids in response to P stress. This remodeling offers a significant competitive advantage for these organisms, allowing them to adapt to oligotrophic environments low in P. In this seminar, I will introduce the lipidomics approaches we use to characterise some novel microbial lipids which we have recently identified in several model bacteria and discuss the ecological and physiological consequences of lipid remodeling in bacteria.
Membrane lipids form the structural basis of all cells. In bacteria Escherichia coli uses predominantly phosphorus-containing phospholipids in its cell envelope, including phosphatidylethanolamine and phosphatidylglycerol. However, beyond E. coli a range of lipids are found in bacterial membranes, including phospholipids as well as phosphorus (P)-free lipids such as betaine lipids, ornithine lipids, sulfolipids and glycolipids. It is well established that P availability significantly affects lipid composition in bacteria, whereby non-P sulfur-containing lipids are used to substitute phospholipids in response to P stress. This remodeling offers a significant competitive advantage for these organisms, allowing them to adapt to oligotrophic environments low in P. In this seminar, I will introduce the lipidomics approaches we use to characterise some novel microbial lipids which we have recently identified in several model bacteria and discuss the ecological and physiological consequences of lipid remodeling in bacteria.