Structural and functional mechanism of ECF-type ABC transporters – from bacteria to plants
11:00am - 12:00pm /
Wednesday 8th August 2018
/ Venue: Lecture Theatre 1 Life Sciences Building
Type: Seminar /
Category: Research
- Luning Liu
- Admission: Free event.
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Energy-coupling factor (ECF) transporters, also known as type-III ABC importers, are widely distributed in bacteria and plants. This unique family of ABC transporters are responsible for the uptake of micronutrient (vitamins, metals etc.) from environment in bacteria. ECF transporters are composed of four subunits, two cytoplasmic ATPases EcfA and EcfA’, and two transmembrane proteins namely EcfS for substrate recognition and EcfT for energy coupling. Extensive studies have been carried out to tackle the transport mechanism of the ECF-type ABC transporters. In recent years, we have solved several structures of ECF transporters including the folate, pantothenate and cobalt holotransporters in inward-open conformation and the substrate-binding component FolT in substrate-binding conformation. The structural information suggests that ECF transporters differ significantly from the canonical ABC transporters in substrate binding, transport path and energy coupling, which was summarized in a probable working model.
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1. Bao et al., Cell Res. 2017. 27(5):675-687.
2. Zhao et al., Nat Commun. 2015. 6:7661.
3. Zhang et al., Proc Natl Acad Sci U S A. 2014. 111(52):18560-5.
4. Zhang et al., Trends Microbiol. 2013. 21(12):652-9.
5. Xu et al., Nature. 2013. 497(7448):268-71.