Professor Tony Hunter

Professor Tony Hunter - uncovering new cancer mechanisms

1:00pm - 2:00pm / Monday 14th October 2024 / Venue: Lecture Theatre 2 Life Sciences Building
Type: Seminar / Category: Research
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'A journey from tyrosine to histidine phosphorylation: uncovering new cancer mechanisms'
Professor Tony Hunter, FRS
Salk Institute, California, USA

Histidine phosphorylation, part of the so-called "hidden phosphoproteome", is a poorly characterised post-translational modification (PTM). Professor Hunter joins us to discuss his team's recent findings which, taken together, suggest that protein-histidine phosphorylation is perturbed in several different human cancer types, affording possible therapeutic opportunities.

In 1979, Professor Hunter made his crucial discovery that unchecked tyrosine phosphorylation in cancerous cells was behind their aberrant growth. Today, thanks to his work and that of many others, over 80 tyrosine kinase inhibitors have been approved for clinical use in the treatment of cancer.