2023
Synthesis of Thieno[3,2-d]pyrimidine Derivatives through Sequential S<sub>N</sub> Ar and Suzuki Reactions as Selective h-NTPDase Inhibitors. (Journal article)
Zaman, G., Ullah, S., Uzair, M., Batool, S., Ahmad, H., Ullah, F., . . . Hassan, A. (2023). Synthesis of Thieno[3,2-d]pyrimidine Derivatives through Sequential S<sub>N</sub> Ar and Suzuki Reactions as Selective h-NTPDase Inhibitors.. ChemMedChem, 18(14), e202300165. doi:10.1002/cmdc.202300165DOI: 10.1002/cmdc.202300165
Zaigham, Z. H., Ullah, S., Pelletier, J., Sévigny, J., Iqbal, J., & Hassan, A. (2023). Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for <i>h</i>-NTPDases.. RSC advances, 13(30), 20909-20915. doi:10.1039/d3ra03874bDOI: 10.1039/d3ra03874b
Structural and functional insight into thiazolidinone derivatives as novel candidates for anticancer drug design: in vitro biological and in-silico strategies. (Journal article)
Channar, P. A., Aziz, M., Ejaz, S. A., Chaudhry, G. -E. -S., Saeed, A., Ujan, R., . . . Saeed, A. (2023). Structural and functional insight into thiazolidinone derivatives as novel candidates for anticancer drug design: in vitro biological and in-silico strategies.. Journal of biomolecular structure & dynamics, 41(3), 942-953. doi:10.1080/07391102.2021.2018045DOI: 10.1080/07391102.2021.2018045
2022
Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases. (Journal article)
Begum, Z., Ullah, S., Akram, M., Uzair, M., Ullah, F., Ahsanullah., . . . Hassan, A. (2022). Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases.. Bioorganic chemistry, 129, 106196. doi:10.1016/j.bioorg.2022.106196DOI: 10.1016/j.bioorg.2022.106196
Steric evaluation of Pyox ligands for asymmetric intermolecular Heck-Matsuda reaction (Journal article)
Bibi, R., Khan, I. U., & Hassan, A. (2022). Steric evaluation of Pyox ligands for asymmetric intermolecular Heck-Matsuda reaction. Tetrahedron Letters, 111, 154204. doi:10.1016/j.tetlet.2022.154204DOI: 10.1016/j.tetlet.2022.154204
A patent review of pharmaceutical and therapeutic applications of oxadiazole derivatives for the treatment of chronic diseases (2013-2021). (Journal article)
Hassan, A., Khan, A. H., Saleem, F., Ahmad, H., & Khan, K. M. (2022). A patent review of pharmaceutical and therapeutic applications of oxadiazole derivatives for the treatment of chronic diseases (2013-2021).. Expert opinion on therapeutic patents, 32(9), 969-1001. doi:10.1080/13543776.2022.2116312DOI: 10.1080/13543776.2022.2116312
Identification of novel C-2 symmetric Bis-Azo-Azamethine molecules as competitive inhibitors of mushroom tyrosinase and free radical scavengers: synthesis, kinetics, and molecular docking studies. (Journal article)
Saeed, A., Ahmed, A., Ali Channar, P., Shabir, G., Hassan, A., Zia-Ur-Rehman., . . . El-Seedi, H. R. (2022). Identification of novel C-2 symmetric Bis-Azo-Azamethine molecules as competitive inhibitors of mushroom tyrosinase and free radical scavengers: synthesis, kinetics, and molecular docking studies.. Journal of biomolecular structure & dynamics, 40(10), 4419-4428. doi:10.1080/07391102.2020.1857841DOI: 10.1080/07391102.2020.1857841
Integration of C-Acylation in the Solid-Phase Synthesis of Peptides and Peptidomimetics Employing Meldrum’s Acid, Phosphorus, and Sulfur Ylides (Journal article)
Rademann, J., Ahsanullah, A., Hassan, A., & Ansari, F. L. (2022). Integration of C-Acylation in the Solid-Phase Synthesis of Peptides and Peptidomimetics Employing Meldrum’s Acid, Phosphorus, and Sulfur Ylides. Synthesis, 54(06), 1503-1517. doi:10.1055/a-1667-3648DOI: 10.1055/a-1667-3648
Goldberg Coupling of Thiazole Substituted Aryl Bromide Demands Stoichiometric Copper Compared to Oxazole (Journal article)
Ahmad, H., Ahmed, W., & Hassan, A. (2022). Goldberg Coupling of Thiazole Substituted Aryl Bromide Demands Stoichiometric Copper Compared to Oxazole. ChemistrySelect, 7(5). doi:10.1002/slct.202103940DOI: 10.1002/slct.202103940
2021
Benzimidazole tethered thioureas as a new entry to elastase inhibition and free radical scavenging: Synthesis, molecular docking, and enzyme inhibitory kinetics (Journal article)
Ujan, R., Channar, P. A., Saeed, A., Abbas, Q., Rafique, H., Ashraf, S., . . . Seo, S. (2021). Benzimidazole tethered thioureas as a new entry to elastase inhibition and free radical scavenging: Synthesis, molecular docking, and enzyme inhibitory kinetics. Journal of Heterocyclic Chemistry, 58(10), 1929-1935. doi:10.1002/jhet.4318DOI: 10.1002/jhet.4318
Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor. (Journal article)
Murtaza, A., Afzal, S., Zaman, G., Saeed, A., Pelletier, J., Sévigny, J., . . . Hassan, A. (2021). Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor.. Bioorganic chemistry, 115, 105240. doi:10.1016/j.bioorg.2021.105240DOI: 10.1016/j.bioorg.2021.105240
Exploring the ability of dihydropyrimidine-5-carboxamide and 5-benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase. (Journal article)
Bibi, M., Qureshi, N. A., Sadiq, A., Farooq, U., Hassan, A., Shaheen, N., . . . Rashid, U. (2021). Exploring the ability of dihydropyrimidine-5-carboxamide and 5-benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase.. European journal of medicinal chemistry, 210, 112986. doi:10.1016/j.ejmech.2020.112986DOI: 10.1016/j.ejmech.2020.112986
2020
Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors. (Journal article)
Ahmad, H., Ullah, S., Rahman, F., Saeed, A., Pelletier, J., Sévigny, J., . . . Iqbal, J. (2020). Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.. European journal of medicinal chemistry, 208, 112759. doi:10.1016/j.ejmech.2020.112759DOI: 10.1016/j.ejmech.2020.112759
<i>E</i>- and chemoselective thia-Michael addition to benzyl allenoate (Journal article)
Bibi, R., Murtaza, A., Khan, K. M., Rehman, Z. U., Saeed, A., Tahir, M. N., & Hassan, A. (2020). <i>E</i>- and chemoselective thia-Michael addition to benzyl allenoate. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 195(12), 969-975. doi:10.1080/10426507.2020.1799365DOI: 10.1080/10426507.2020.1799365
A combine approach of chemical synthesis, biological evaluation and structural dynamics studies revealed thiazole substituted arylamine derivatives as potent FabH enzyme inhibitors. (Journal article)
Ahmad, H., Ahmad, F., Parveen, S., Ahmad, S., Azam, S. S., & Hassan, A. (2020). A combine approach of chemical synthesis, biological evaluation and structural dynamics studies revealed thiazole substituted arylamine derivatives as potent FabH enzyme inhibitors.. Bioorganic chemistry, 105, 104426. doi:10.1016/j.bioorg.2020.104426DOI: 10.1016/j.bioorg.2020.104426
Nitroxide-mediated radical polymerization of methacryloisobutyl POSS and its block copolymers with poly(<i>n</i>-acryloylmorpholine) (Journal article)
Ullah, A., Shah, S. M., Hassan, A., Maric, M., & Hussain, H. (2020). Nitroxide-mediated radical polymerization of methacryloisobutyl POSS and its block copolymers with poly(<i>n</i>-acryloylmorpholine). JOURNAL OF POLYMER SCIENCE, 58(3), 428-437. doi:10.1002/pol.20190108DOI: 10.1002/pol.20190108
Recent developments in the synthesis of regioregular thiophene-based conjugated polymers for electronic and optoelectronic applications using nickel and palladium-based catalytic systems (Journal article)
Amna, B., Siddiqi, H. M., Hassan, A., & Ozturk, T. (2020). Recent developments in the synthesis of regioregular thiophene-based conjugated polymers for electronic and optoelectronic applications using nickel and palladium-based catalytic systems. RSC ADVANCES, 10(8), 4322-4396. doi:10.1039/c9ra09712kDOI: 10.1039/c9ra09712k
Computational and biological studies of novel thiazolyl coumarin derivatives synthesized through Suzuki coupling (Journal article)
Parveen, S., Kalsoom, S., Bibi, R., Asghar, A., Hameed, A., Ahmed, W., & Hassan, A. (2020). Computational and biological studies of novel thiazolyl coumarin derivatives synthesized through Suzuki coupling. Turkish Journal of Chemistry, 44(6), 1610-1622. doi:10.3906/kim-2007-19DOI: 10.3906/kim-2007-19
Parveen, S., Kalsoom, S., Bibi, R., Asghar, A., Hameed, A., Ahmed, W., & Hassan, A. (2020). Computational and biological studies of novel thiazolyl coumarin derivatives synthesized through Suzuki coupling.. Turkish journal of chemistry, 44(6), 1610-1622. doi:10.3906/kim-2005-19DOI: 10.3906/kim-2005-19
2019
Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies. (Journal article)
Hayat, K., Afzal, S., Saeed, A., Murtaza, A., Ur Rahman, S., Khan, K. M., . . . Hassan, A. (2019). Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies.. Bioorganic chemistry, 87, 218-226. doi:10.1016/j.bioorg.2019.03.019DOI: 10.1016/j.bioorg.2019.03.019
Design, synthesis and bioevaluation of tricyclic fused ring system as dual binding site acetylcholinesterase inhibitors. (Journal article)
Tanoli, S. T., Ramzan, M., Hassan, A., Sadiq, A., Jan, M. S., Khan, F. A., . . . Rashid, U. (2019). Design, synthesis and bioevaluation of tricyclic fused ring system as dual binding site acetylcholinesterase inhibitors.. Bioorganic chemistry, 83, 336-347. doi:10.1016/j.bioorg.2018.10.035DOI: 10.1016/j.bioorg.2018.10.035
Current Progress in Nitrogen Based Chiral Ligands for Pd-catalyzed Asymmetric Transformations (Journal article)
Khan, I. U., Bibi, R., & Hassan, A. (2018). Current Progress in Nitrogen Based Chiral Ligands for Pd-catalyzed Asymmetric Transformations. CURRENT ORGANIC CHEMISTRY, 22(25), 2460-2486. doi:10.2174/1385272822666181029114145DOI: 10.2174/1385272822666181029114145
2018
Modification of Bischler-Möhlau indole derivatives through palladium catalyzed Suzuki reaction as effective cholinesterase inhibitors, their kinetic and molecular docking studies. (Journal article)
Parveen, S., Shah, M. S., Zaib, S., Gul, T., Khan, K. M., Iqbal, J., & Hassan, A. (2018). Modification of Bischler-Möhlau indole derivatives through palladium catalyzed Suzuki reaction as effective cholinesterase inhibitors, their kinetic and molecular docking studies.. Bioorganic chemistry, 76, 166-176. doi:10.1016/j.bioorg.2017.11.003DOI: 10.1016/j.bioorg.2017.11.003
Sensitive and Selective Detection of Multiple Metal Ions Using Amino Acids Modified Glassy Carbon Electrodes (Journal article)
Nisar, A., Shah, A., Zahid, A., Iftikhar, F. J., Hassan, A., Shah, A. H., . . . Kraatz, H. -B. (2018). Sensitive and Selective Detection of Multiple Metal Ions Using Amino Acids Modified Glassy Carbon Electrodes. JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 165(3), B67-B73. doi:10.1149/2.0151803jesDOI: 10.1149/2.0151803jes
Sensitive and selective detection of multiple metal ions using amino acids modified glassy carbon electrodes (Journal article)
Nisar, A., Shah, A., Zahid, A., Iftikhar, F. J., Hassan, A., Shah, A. H., . . . Kraatz, H. B. (2018). Sensitive and selective detection of multiple metal ions using amino acids modified glassy carbon electrodes. Journal of the Electrochemical Society, 165(3), B67-B73. doi:10.1149/2.0151803jes]DOI: 10.1149/2.0151803jes]
2017
Pd-PEPPSI-IPent-SiO<sub>2</sub> : A Supported Catalyst for Challenging Negishi Coupling Reactions in Flow. (Journal article)
Price, G. A., Hassan, A., Chandrasoma, N., Bogdan, A. R., Djuric, S. W., & Organ, M. G. (2017). Pd-PEPPSI-IPent-SiO<sub>2</sub> : A Supported Catalyst for Challenging Negishi Coupling Reactions in Flow.. Angewandte Chemie (International ed. in English), 56(43), 13347-13350. doi:10.1002/anie.201708598DOI: 10.1002/anie.201708598
Pd‐PEPPSI‐IPent‐SiO<sub>2</sub>: A Supported Catalyst for Challenging Negishi Coupling Reactions in Flow (Journal article)
Price, G. A., Hassan, A., Chandrasoma, N., Bogdan, A. R., Djuric, S. W., & Organ, M. G. (2017). Pd‐PEPPSI‐IPent‐SiO<sub>2</sub>: A Supported Catalyst for Challenging Negishi Coupling Reactions in Flow. Angewandte Chemie, 129(43), 13532-13535. doi:10.1002/ange.201708598DOI: 10.1002/ange.201708598
Design, synthesis, in vitro Evaluation and docking studies on dihydropyrimidine-based urease inhibitors. (Journal article)
Iftikhar, F., Ali, Y., Ahmad Kiani, F., Fahad Hassan, S., Fatima, T., Khan, A., . . . Rashid, U. (2017). Design, synthesis, in vitro Evaluation and docking studies on dihydropyrimidine-based urease inhibitors.. Bioorganic chemistry, 74, 53-65. doi:10.1016/j.bioorg.2017.07.003DOI: 10.1016/j.bioorg.2017.07.003
Chemo-, Regio-, and Enantioselective Rhodium-Catalyzed Allylation of Pyridazinones with Terminal Allenes. (Journal article)
Parveen, S., Li, C., Hassan, A., & Breit, B. (2017). Chemo-, Regio-, and Enantioselective Rhodium-Catalyzed Allylation of Pyridazinones with Terminal Allenes.. Organic letters, 19(9), 2326-2329. doi:10.1021/acs.orglett.7b00718DOI: 10.1021/acs.orglett.7b00718
2016
Enantioselective total synthesis of the highly selective sphingosine-1-receptor VPC01091 by the Heck desymmetrization of a non-activated cyclopentene-fused spiro-pyrrolidinone. (Journal article)
Khan, I. U., Kattela, S., Hassan, A., & Correia, C. R. D. (2016). Enantioselective total synthesis of the highly selective sphingosine-1-receptor VPC01091 by the Heck desymmetrization of a non-activated cyclopentene-fused spiro-pyrrolidinone.. Organic & biomolecular chemistry, 14(40), 9476-9480. doi:10.1039/c6ob01892kDOI: 10.1039/c6ob01892k
Anticancer activity, DNA-binding and DNA-denaturing aptitude of palladium(II) dithiocarbamates (Journal article)
Amir, M. K., Khan, S. Z., Hayat, F., Hassan, A., Butler, I. S., & Zia-ur-Rehman. (2016). Anticancer activity, DNA-binding and DNA-denaturing aptitude of palladium(II) dithiocarbamates. INORGANICA CHIMICA ACTA, 451, 31-40. doi:10.1016/j.ica.2016.06.036DOI: 10.1016/j.ica.2016.06.036
2015
Humidity-sensing and DNA-binding ability of bis (4-benzylpiperazine-1-carbodithioato-<i>k<SUP>2</SUP></i> <i>S</i>,<i>S</i>′)nickel(II) (Journal article)
Rehman, M. -U., Imran, M., Zia-Ur-Rehman., Hassan, A., Badshah, A., Shah, A., . . . Shah, G. (2015). Humidity-sensing and DNA-binding ability of bis (4-benzylpiperazine-1-carbodithioato-<i>k<SUP>2</SUP></i> <i>S</i>,<i>S</i>′)nickel(II). JOURNAL OF COORDINATION CHEMISTRY, 68(2), 295-307. doi:10.1080/00958972.2014.977880DOI: 10.1080/00958972.2014.977880
2012
Enantioselective conversion of primary alcohols to α-exo-methylene γ-butyrolactones via iridium-catalyzed C-C bond-forming transfer hydrogenation: 2-(alkoxycarbonyl)allylation. (Journal article)
Montgomery, T. P., Hassan, A., Park, B. Y., & Krische, M. J. (2012). Enantioselective conversion of primary alcohols to α-exo-methylene γ-butyrolactones via iridium-catalyzed C-C bond-forming transfer hydrogenation: 2-(alkoxycarbonyl)allylation.. Journal of the American Chemical Society, 134(27), 11100-11103. doi:10.1021/ja303839hDOI: 10.1021/ja303839h
Consecutive iridium catalyzed C-C and C-H bond forming hydrogenations for the diastereo- and enantioselective synthesis of syn-3-fluoro-1-alcohols: C-H (2-fluoro)allylation of primary alcohols. (Journal article)
Hassan, A., Montgomery, T. P., & Krische, M. J. (2012). Consecutive iridium catalyzed C-C and C-H bond forming hydrogenations for the diastereo- and enantioselective synthesis of syn-3-fluoro-1-alcohols: C-H (2-fluoro)allylation of primary alcohols.. Chemical communications (Cambridge, England), 48(39), 4692-4694. doi:10.1039/c2cc31743eDOI: 10.1039/c2cc31743e
2011
Unlocking Hydrogenation for C-C Bond Formation: A Brief Overview of Enantioselective Methods. (Journal article)
Hassan, A., & Krische, M. J. (2011). Unlocking Hydrogenation for C-C Bond Formation: A Brief Overview of Enantioselective Methods.. Organic process research & development, 15(6), 1236-1242. doi:10.1021/op200195mDOI: 10.1021/op200195m
Catalytic enantioselective Grignard Nozaki-Hiyama methallylation from the alcohol oxidation level: chloride compensates for π-complex instability. (Journal article)
Hassan, A., Townsend, I. A., & Krische, M. J. (2011). Catalytic enantioselective Grignard Nozaki-Hiyama methallylation from the alcohol oxidation level: chloride compensates for π-complex instability.. Chemical communications (Cambridge, England), 47(36), 10028-10030. doi:10.1039/c1cc14392aDOI: 10.1039/c1cc14392a
Enantioselective iridium-catalyzed vinylogous Reformatsky-aldol reaction from the alcohol oxidation level: linear regioselectivity by way of carbon-bound enolates. (Journal article)
Hassan, A., Zbieg, J. R., & Krische, M. J. (2011). Enantioselective iridium-catalyzed vinylogous Reformatsky-aldol reaction from the alcohol oxidation level: linear regioselectivity by way of carbon-bound enolates.. Angewandte Chemie (International ed. in English), 50(15), 3493-3496. doi:10.1002/anie.201100646DOI: 10.1002/anie.201100646
2010
Total synthesis of (+)-roxaticin via C-C bond forming transfer hydrogenation: a departure from stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles in polyketide construction. (Journal article)
Han, S. B., Hassan, A., Kim, I. S., & Krische, M. J. (2010). Total synthesis of (+)-roxaticin via C-C bond forming transfer hydrogenation: a departure from stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles in polyketide construction.. Journal of the American Chemical Society, 132(44), 15559-15561. doi:10.1021/ja1082798DOI: 10.1021/ja1082798
2009
Elongation of 1,3-polyols via iterative catalyst-directed carbonyl allylation from the alcohol oxidation level. (Journal article)
Hassan, A., Lu, Y., & Krische, M. J. (2009). Elongation of 1,3-polyols via iterative catalyst-directed carbonyl allylation from the alcohol oxidation level.. Organic letters, 11(14), 3112-3115. doi:10.1021/ol901136wDOI: 10.1021/ol901136w
1,n-glycols as dialdehyde equivalents in iridium-catalyzed enantioselective carbonyl allylation and iterative two-directional assembly of 1,3-polyols. (Journal article)
Lu, Y., Kim, I. S., Hassan, A., Del Valle, D. J., & Krische, M. J. (2009). 1,n-glycols as dialdehyde equivalents in iridium-catalyzed enantioselective carbonyl allylation and iterative two-directional assembly of 1,3-polyols.. Angewandte Chemie (International ed. in English), 48(27), 5018-5021. doi:10.1002/anie.200901648DOI: 10.1002/anie.200901648
2008
Diastereo- and Enantioselective Reductive Aldol Addition of Vinyl Ketones via Catalytic Hydrogenation. (Journal article)
Han, S. B., Hassan, A., & Krische, M. J. (2008). Diastereo- and Enantioselective Reductive Aldol Addition of Vinyl Ketones via Catalytic Hydrogenation.. Synthesis, 2008(17), 2669-2679. doi:10.1055/s-2008-1067220DOI: 10.1055/s-2008-1067220
Diastereo- and enantioselective hydrogenative aldol coupling of vinyl ketones: design of effective monodentate TADDOL-like phosphonite ligands. (Journal article)
Bee, C., Han, S. B., Hassan, A., Iida, H., & Krische, M. J. (2008). Diastereo- and enantioselective hydrogenative aldol coupling of vinyl ketones: design of effective monodentate TADDOL-like phosphonite ligands.. Journal of the American Chemical Society, 130(9), 2746-2747. doi:10.1021/ja710862uDOI: 10.1021/ja710862u
