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LONGEVITY Publications

Browse our archive of publications resulting from LONGEVITY project activities below.

Publications

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Publication date
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TitleKeywordsAuthorsJournal
2024-03-28

Preferences and feasibility of long-acting technologies for treatment of hepatitis C virus in low- and middle-income countries: A survey of providers and policymakers

hepatitis C virus, community survey, LMICs. Gupta, N., Swindells, S., Scarsi, K.K., Furl, R., Thomas, D.L., Weld, E.D., Dountio Ofimboudem, J., Desalegn, H., Hamid, S., de la Torre Rosasa, A., Miranda, A.E., Owen, A., Rannard, S., Hiebert, L., Sun, K., & Ward, J.W. Journal of Viral Hepatitis
2023-11-30 Physiologically Based Pharmacokinetic Modelling of Cabotegravir Microarray Patches in Rats and Humans HIV, cabotegravir, antiretroviral, microarray patches Kinvig, H., Rajoli, R.K.R., Pertinez, H., Vora, L.K., Volpe-Zanutto, F., Donnelly, R., Rannard, S., Flexner, C., Siccardi, M., & Owen, A. Pharmaceutics
2023-11-23 Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters sars-cov-2, antiviral Box, H.J., Sharp, J., Pennington, S.H., Kijak, E., Tatham, L., Caygill, C.H., Lopeman, R.C., Jeffreys, L.N., Herriott, J., Neary, M., Valentijn, A., Pertinez, H., Curley, P., Arshad, U,. Rajoli, R.K.R., Jochmans, D., Vangeel, L., Neyts, J., Chatelain, E., Escudié, F., Scandale, I., Rannard, S., Stewart, J.P., Biagini, G.A., & Owen, A. Journal of Antimicrobial Chemotherapy
2023-10-27 Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters sars-cov-2 Gallardo-Toledo, E., Neary, M., Sharp, J., Herriott, J., Kijak, E., Bramwell, C., Curley, P., Arshad, U., Pertinez, H., Rajoli, R.K.R., Valentijn, A., Cox, H., Tatham, L., Kipar, A., Stewart, J., & Owen, A. Viruses
2023-10-25 Development and validation of a liquid chromatographic-tandem mass spectrometric assay for the quantification of the direct acting antivirals glecaprevir and pibrentasvir in plasma hepatitis C virus, glecaprevir, pibrenstasvir Garza, K.Y., Pandey, A., & Marzinke, M.A. Journal of Pharmaceutical and Biomedical Analysis
2023-10-13 An Open Label, Adaptive, Phase 1 Trial of High‐Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS‐CoV‐2 sars-cov-2, nitazoxanide, antiviral Walker, L.E., FitzGerald, R., Saunders, G., Lyon, R., Fisher, M., Martin, K., Eberhart, I., Woods, C., Ewings, S., Hale, C., Rajoli, R.K.R., Else, L., Dilly-Penchala, S., Amara, A., Lalloo, D.G., Jacobs, M., Pertinez, H., Hatchard, P., Waugh, R., Lawrence, M., Johnson, L., Fines, K., Reynolds, H., Rowland, T., Crook, R., Okenyi, E., Byrne, K., Mozgunov, P., Jaki, T., Khoo, S., Owen, A., Griffiths, G., & Fletcher, T.E. Clinical Pharmacology & Therapeutics
2023-10-12 Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito malaria, atovaquone  Balta, V.A., Stiffler, D., Sayeed, A., Tripathi, A.K., Elahi, R., Mlambo, G., Bakshi, R.P., Dziedzic, A.G., Jedlicka, A.E., Nenortas, E., Romero-Rodriguez, K., Canonizado, M.A., Mann, A., Owen, A., Sullivan, D.J. Prigge, S.T., Sinnis, P., & Shapiro, T.A. Nature Communications
2023-08-21 Preferences of Patients and Providers in High-Burden Malaria Settings for Long-Acting Malaria Chemoprevention malaria, survey Scarsi, K.K., Sayles, H., Kapungu, K., Sifuna, P., Ippolito, M.M., Furl, R., Anderson, M.J., Dountio Ofimboudem, J., Chongwe, G., Hutter, J., Rannard, S., Owen, A., & Swindells, S. The American Journal of Tropical Medicine and Hygiene
2023-08-15 Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters nafamostat, sars-cov-2 Neary, M., Sharp, J., Gallardo-Toledo, E., Herriott, J., Kijak, E., Bramwell, C., Cox, H., Tatham, L., Box, H., Curley, P., Ashad, U., Rajoli, R.K.R, Pertinez, H., Valentijn, A., Dhaliwal, K., Mc Caughan, F., Hobson, J., Rannard, S., Kipar, A., Stewart, J., & Owen, A. Viruses
2023-06-14 Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy tuberculosis, rifapentine, rifabutin Chang, Y.S., Li, S.Y., Pertinez, H., Betoudji, F., Lee, J., Rannard, S., Owen, A., Nuermberger, E.L., & Ammerman, N.C. Antimicrobial Agents and Chemotherapy
2023-03-09 Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case Ronapreve, sars-cov-2 Tatham, L., Kipar, A., Sharp, J., Kijak, E., Herriott, J., Neary, M., Box, H., Gallardo Toledo, E., Valentijn, A., Cox, H., Pertinez, H., Curley, P., Arshad, U., Rajoli, R.K., Rannard, S., Stewart, J., & Owen, A. bioRxiv
2022-12-05 FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2 fxr inhibitor, sars-cov-2, ace2 Brevini, T., Maes, M., Webb, G. J., John, B. V., Fuchs, C. D., Buescher, G., & Sampaziotis, F.  Nature 
2022-11-21 Prospects for Long-Acting Treatments for Hepatitis C hepatitis C virus  Thomas, D. L., Owen, A., & Kiser, J. J.  Clinical Infectious Diseases  

 

 

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Our funding

The LONGEVITY Project is funded by Unitaid

The Unitaid logo is the organisation name written above the words

The project also involves critical partners and collaborators in the Clinton Health Access Initiative, Johns Hopkins University, Medicines Patent Pool, Tandem Nano Ltd., Treatment Action Group and the University of Nebraska Medical Center

The Clinton Health Access Initiative logo is the name with a ring of stars flying from itJohns Hopkins University logo is the Institution name under its crestThe Medicines Patent Pool logo is the organisation name to the right of three interconnecting circlesThe Tandem Nano Ltd logo is the organisation name to the right of a stylised letter T graphicThe Treatment Action Group logo is the Acronym The UNMC logo is the initialisation with the words