An image of equipment at the Centre for Proteome Research

Our facilities

We have 11 mass spectrometers permitting a range of different protein and peptide-based analyses using a variety of different separation and ionisation processes. Different fragmentation capabilities, including high and low energy collision-induced dissociation (CID, HCD), electron transfer dissociation (ETD) and Ultraviolet Photodissociation (UVPD) offers enhanced capabilities for characterisation of proteins and their modifications.

Instruments

An image of the Thermo Scientific Q-Exactive at the Centre for Proteome Research

  • Thermo Scientific Q-Exactive
  • Thermo Scientific Q-Exactive HF
  • Thermo Scientific Orbitrap Fusion with FAIMSpro
  • Thermo Scientific Orbitrap Lumos with FAIMSpro
  • Thermo Scientific Exploris 480 with FAIMSpro
  • Waters Xevo TQ-S
  • Waters Synapt G2Si HDMS with ETD
  • Bruker TimsTOF HT
  • Bruker TimsTOF SCP

Online capabilities

Each instrument is capable of coupling to at least one of the online separation techniques or specialist ionisation sources listed below.

An image of the Thermo Scientific U3000 UPLC at the Centre for Proteome Research

  • Thermo Scientific U3000 UPLC
  • Waters NanoAcquity UPLC
  • SCIEX 8000+ capillary electrophoresis
  • Thermo Scientific HESI Probe
  • Waters REIMS Source
  • Waters MALDI Source
  • Waters DESI Source.
  • EvoSep

Offline capabilities

  • High pH Fractionation
  • Protein purification
  • De-Salting
  • Phosphopeptide enrichment
  • Opentron robotic system.

Non-mass spec capabilities

An image of protein sample equipment at the Centre for Proteome Research

  • Protein Simple. Milo, Single-cell Western Blot
  • Protein Simple. Wes, Capillary western blotting.

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