2019

Outputs from 2019

Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies. 

  • Atoyebi SA, Rajoli RKR, Adejuyigbe E, Owen A, Bolaji O, Siccardi M, Olagunju A. (2019) European Journal of Pharmaceutical Sciences 
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Recommendations for the Use of Social Media in Pharmacovigilance: Lessons from IMI WEB-RADR.

  • van Stekelenborg J, Ellenius J, Maskell S, Bergvall T, Caster O, Dasgupta N, . . . Pirmohamed M. (2019) Drug Safety 
  • Click to read the paper

 

The skin as a metabolic and immune-competent organ: Implications for drug-induced skin rash.

  • Sharma A, Saito Y, Hung SI, Naisbitt D, Uetrecht J, Bussiere J. (2019)  Journal of Immunotoxicology
  • Click to read the paper

 

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells.

  • Penman SL, Sharma P, Aerts H, Park BK, Weaver RJ, Chadwick AE. (2019) Toxicology in Vitro
  • Click to read the paper

 

Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink.

  • Carr DF, Francis B, Jorgensen AL, Zhang E, Chinoy H, Heckbert SR, . . . Pirmohamed M. (2019)  Clinical Pharmacology and Therapeutics
  • Click to read the paper

 

Clinical Pharmacodynamics, Pharmacokinetics, and Drug Interaction Profile of Doravirine.

 

Biomarker-guided trials: Challenges in practice.

  • Antoniou M, Kolamunnage-Dona R, Wason J, Bathia R, Billingham C, Bliss JM, . . . Jorgensen AL. (2019)  Contemporary Clinical Trials Communications
  • Click to read the paper

 

NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells.

  • Jones LG, Vaida A, Thompson LM, Ikuomola FI, Caamaño JH, Burkitt MD, . . . Duckworth CA. (2019)  Cell Death and Disease
  • Click to read the paper

 

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

  • Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, . . . Park BK. (2019)  Nature Reviews Drug Discovery
  • Click to read the paper

 

T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity.

 

Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury.

 

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.

  • Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, . . . Tyndale RF. (2019)  Clinical Pharmacology and Therapeutics
  • Click to read the paper

 

Prescribing in liver disease.

 

Genetic Predisposition to Anticonvulsant Hypersensitivity.

 

Exosomal Transport of Hepatocyte-Derived Drug-Modified Proteins to the Immune System.

  • Ogese MO, Jenkins RE, Adair K, Tailor A, Meng X, Faulkner L, . . . Betts C. (2019)  Hepatology
  • Click to read the paper

 

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.

  • Nicoletti P, Barrett S, McEvoy L, Daly AK, Aithal G, Lucena MI, . . . Pirmohamed M. (2019)  Clinical Pharmacology and Therapeutics
  • Click to read the paper

 

In silico-guided optimisation of oxygen gradients in hepatic spheroids.

  • Leedale J, Colley HE, Gaskell H, Williams DP, Bearon RN, Chadwick AE, . . . Webb SD. (2019) Computational Toxicology
  • Click to read the paper

 

Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo.

  • Tailor A, Waddington JC, Hamlett J, Maggs J, Kafu L, Farrell J, . . . Meng X. (2019)  Chemical Research in Toxicology
  • Click to read the paper

 

The development and validation of a novel LC–MS/MS method for the quantification of cenicriviroc in human plasma and cerebrospinal fluid.

  • Dilly Penchala S, Alagaratnam J, Challenger E, Amara A, Else L, Winston A, Khoo S. (2019) Biomedical Chromatography
  • Click to read the paper

 

Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways.

  • Perkins EJ, Gayen K, Shoemaker JE, Antczak P, Burgoon L, Falciani F, . . . Garcia-Reyero N. (2019)  Altex
  • Click to read the paper

 

Physiologically Based Pharmacokinetic Modelling to Identify Pharmacokinetic Parameters Driving Drug Exposure Changes in the Elderly.

  • Stader F, Kinvig H, Penny MA, Battegay M, Siccardi M, Marzolini C. (2019)  Clinical Pharmacokinetics
  • Click to read the paper

 

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients.

  • Papoutsopoulou S, Burkitt MD, Bergey F, England H, Hough R, Schmidt L, . . . Probert CS. (2019)  Frontiers in Immunology
  • Click to read the paper

 

Immunotoxicity Considerations for Next Generation Cancer Nanomedicines.

 

Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART.

  • Neary M, Chappell CA, Scarsi KK, Nakalema S, Matovu J, Achilles SL, . . . Lamorde M. (2019)  The Journal of antimicrobial chemotherapy
  • Click to read the paper

 

Dose-linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children.

  • van Groen BD, Vaes WH, Park BK, Krekels EHJ, van Duijn E, Kõrgvee LT, . . . Turner MA. (2019)  British Journal of Clinical Pharmacology
  • Click to read the paper

 

Imaging of cancer lipid metabolism in response to therapy.

 

Critical considerations for targeting colorectal liver metastases with nanotechnology.

  • Arshad U, Sutton PA, Ashford MB, Treacher KE, Liptrott NJ, Rannard SP, . . . Owen A. (2019)  Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
  • Click to read the paper

 

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation.

  • Thomson PJ, Illing PT, Farrell J, Alhaidari M, Bell CC, Berry N, . . . Naisbitt DJ. (2019)  Allergy: European Journal of Allergy and Clinical Immunology
  • Click to read the paper

 

Measuring Kidney Perfusion, pH, and Renal Clearance Consecutively Using MRI and Multispectral Optoacoustic Tomography.

  • Minhas AS, Sharkey J, Randtke EA, Murray P, Wilm B, Pagel MD, Poptani H. (2019)  Molecular Imaging and Biology
  • Click to read the paper

 

Pharmacokinetics of maraviroc in plasma and breastmilk in a treatment-experienced perinatally HIV-1 infected women.

 

Evidence to support inclusion of pharmacogenetic biomarkers in randomised controlled trials.

  • Johnson D, Hughes D, Pirmohamed SM, Jorgensen A. (2019)  Journal of Personalized Medicine
  • Click to read the paper

 

Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study).

  • Waitt C, Orrell C, Walimbwa S, Singh Y, Kintu K, Simmons B, . . . Khoo S. (2019)  PLoS Medicine
  • Click to read the paper

 

Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid-Overlay Technique.

 

Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: An open label non-randomized interventional trial.

  • Sevene E, Banda CG, Mukaka M, Maculuve S, Macuacua S, Vala A, . . . Mwapasa V. (2019)  Malaria Journal
  • Click to read the paper

 

Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01.

  • Zhao Q, Alhilali K, Alzahrani A, Almutairi M, Amjad J, Liu H, . . . Naisbitt DJ. (2019)  Allergy: European Journal of Allergy and Clinical Immunology
  • Click to read the paper

 

Pharmacodynamics of tebipenem: New options for oral treatment of multidrug-resistant gram-negative infections.

  • McEntee L, Johnson A, Farrington N, Unsworth J, Dane A, Jain A, . . . Hope W. (2019)  Antimicrobial Agents and Chemotherapy
  • Click to read the paper

 

Educating the Next Generation of Pharmacogenomics Experts: Global Educational Needs and Concepts.

  • Just KS, Turner RM, Dolžan V, Cecchin E, Swen JJ, Gurwitz D, Stingl J. (2019) Clinical Pharmacology and Therapeutics
  • Click to read the paper

 

Bridging communities in the field of nanomedicine.

  • Halamoda-Kenzaoui B, Baconnier S, Bastogne T, Bazile D, Boisseau P, Borchard G, . . . Bremer-Hoffmann S. (2019)  Regulatory Toxicology and Pharmacology
  • Click to read the paper

 

Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement.

  • Goldman JL, Chung WH, Lee BR, Chen CB, Lu CW, Hoetzenecker W, . . . Pirmohamed M. (2019)  European Journal of Clinical Pharmacology
  • Click to read the paper

 

Public involvement in the dissemination of the North West Coast Household Health Survey: Experiences and lessons of co-producing research together.

  • Giebel C, Hassan S, McIntyre JC, Corcoran R, Barr B, Gabbay M, . . . Alfirevic A. (2019)  Health Expectations
  • Click to read the paper

 

Long-acting injectable statins—is it time for a paradigm shift?

 

Genetic testing for prevention of severe drug-induced skin rash.

  • Alfirevic A, Pirmohamed M, Marinovic B, Harcourt-Smith L, Jorgensen AL, Cooper TE. (2019)  Cochrane Database of Systematic Reviews
  • Click to read the paper

 

Protocol for the development of the STrengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline: Checklist of items for reporting pharmacogenetic studies.

 

Nilotinib-induced metabolic dysfunction: insights from a translational study using in vitro adipocyte models and patient cohorts.

  • Sadiq S, Owen E, Foster T, Knight K, Wang L, Pirmohamed M, . . . Pushpakom S. (2019)  Leukemia
  • Click to read the paper

 

HLA- and immune-mediated adverse drug reactions: Another hit with vancomycin.

 

Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles.

  • Nicoletti P, Aithal GP, Chamberlain TC, Coulthard S, Alshabeeb M, Grove JI, . . . Daly AK. (2019)  Clinical Pharmacology and Therapeutics
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Optimizing responses to drug safety signals in pregnancy: the example of dolutegravir and neural tube defects.

  • Mofenson LM, Pozniak AL, Wambui J, Raizes E, Ciaranello A, Clayden P, . . . Ford NP. (2019)  Journal of the International AIDS Society
  • Click to read the paper

 

Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens–Johnson syndrome/toxic epidermal necrolysis.

  • Carr DF, Wang CW, Bellón T, Ressel L, Nwikue G, Shrivastava V, . . . Pirmohamed M. (2019)  British Journal of Dermatology
  • Click to read the paper

 

DNA extraction and amplicon production strategies deeply inf luence the outcome of gut mycobiome studies.

  • Frau A, Kenny JG, Lenzi L, Campbell BJ, Ijaz UZ, Duckworth CA, . . . Probert CSJ. (2019)  Scientific Reports
  • Click to read the paper

 

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.

  • Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, . . . Alfirevic A. (2019)  PLoS ONE
  • Click to read the paper

 

Replication of crohn’s disease mucosal E. Coli isolates inside macrophages correlates with resistance to superoxide and is dependent on macrophage Nf-kappa B activation.

  • Tawfik A, Knight P, Duckworth CA, Pritchard DM, Rhodes JM, Campbell BJ. (2019)  Pathogens
  • Click to read the paper

 

Reply to Banda et al., “Interpretation of drug interactions between dolutegravir and artemether-lumefantrine or artesunate-amodiaquine”.

  • Walimbwa S, Lamorde M, Waitt C, Amara A, Khoo S. (2019)  Antimicrobial Agents and Chemotherapy
  • Click to read the paper

 

Cost-Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework.

 

Population pharmacokinetic modeling of VL-2397, a novel systemic antifungal agent: Analysis of a single- And multiple-ascending-dose study in healthy subjects.

  • Kovanda LL, Sullivan SM, Smith LR, Desai AV, Bonate PL, Hope WW. (2019)  Antimicrobial Agents and Chemotherapy
  • Click to read the paper

 

Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity.

  • Kamalian L, Douglas O, Jolly CE, Snoeys J, Simic D, Monshouwer M, . . . Chadwick AE. (2019) Current Protocols in Toxicology
  • Click to read the paper

 

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.

  • Hernandez-Pacheco N, Farzan N, Francis B, Karimi L, Repnik K, Vijverberg SJ, . . . Pino-Yanes M. (2019)  Clinical and Experimental Allergy
  • Click to read the paper

 

Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics.

  • Fitzgerald G, Prince C, Downing J, Reynolds J, Zhang JE, Hanson A, . . . Pirmohamed M. (2019)  Pharmacogenomics
  • Click to read the paper

 

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.

  • Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, . . . Fava C. (2019)  Clinical Pharmacology and Therapeutics
  • Click to read the paper

 

Efficacy and safety of artemether-lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: An open label non-randomized interventional trial.

  • Banda CG, Chaponda M, Mukaka M, Mulenga M, Hachizovu S, Kabuya JB, . . . Mwapasa V. (2019)  Malaria Journal
  • Click to read the paper

 

Fifteen-minute consultation: Pharmacogenomics: a guide for busy clinicians.

  • Parry CM, Hawcutt D. (2019)  Archives of Disease in Childhood: Education and Practice Edition
  • Click to read the paper

 

Predicting drug-drug interactions between rifampicin and long-acting cabotegravir and rilpivirine using physiologically based pharmacokinetic modeling

  • Rajoli RKR, Curley P, Chiong J, Back D, Flexner C, Owen A, Siccardi M. (2019) Journal of Infectious Diseases
  • Click to read the paper

 

Carbamazepine intervention in a patient with efavirenz-induced liver injury.

 

Overview of the blood compatibility of nanomedicines: A trend analysis of in vitro and in vivo studies

  • Urbán P, Liptrott NJ, Bremer S. (2019) . Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
  • Click to read the paper

 

Towards a Maraviroc long-acting injectable nanoformulation.

  • Tatham LM, Savage AC, Dwyer A, Siccardi M, Scott T, Vourvahis M, . . . Owen A. (2019)  European Journal of Pharmaceutics and Biopharmaceutics
  • Click to read the paper

 

Improving maraviroc oral bioavailability by formation of solid drug nanoparticles.

  • Savage AC, Tatham LM, Siccardi M, Scott T, Vourvahis M, Clark A, . . . Owen A. (2019) European Journal of Pharmaceutics and Biopharmaceutics
  • Click to read the paper

 

SFX-01 reduces residual disability after experimental autoimmune encephalomyelitis.

  • Galea I, Copple IM, Howat DW, Franklin S. (2019)  Multiple Sclerosis and Related Disorders
  • Click to read the paper

 

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

  • Cirulli ET, Nicoletti P, Abramson K, Andrade RJ, Bjornsson ES, Chalasani N, . . . Wadelius M. (2019)  Gastroenterology
  • Click to read the paper

 

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism.

  • Kelly RA, Leedale J, Calleja D, Enoch SJ, Harrell A, Chadwick AE, Webb S. (2019) Scientific Reports
  • Click to read the paper

 

Stem cell models as an in vitro model for predictive toxicology.

  • Lynch S, Pridgeon CS, Duckworth CA, Sharma P, Park BL, Goldring CEP. (2019)  Biochemical Journal
  • Click to read the paper

 

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: A matched cohort study.

  • Jorgensen AL, Prince C, Fitzgerald G, Hanson A, Downing J, Reynolds J, . . . Pirmohamed M. (2019)  BMC Medicine
  • Click to read the paper

 

A systematic review of the effects of implementing clinical pathways supported by health information technologies.

  • Neame MT, Chacko J, Surace AE, Sinha IP, Hawcutt DB. (2019)  Journal of the American Medical Informatics Association
  • Click to read the paper

 

CSF penetration of vancomycin in critical care patients with proven or suspected ventriculitis: A prospective observational study.

  • Blassmann U, Hope W, Roehr AC, Frey OR, Vetter-Kerkhoff C, Thon N, . . . Huge V. (2019) Journal of Antimicrobial Chemotherapy
  • Click to read the paper

 

Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers.

  • Alhilali KA, Al-Attar Z, Gibson A, Tailor A, Meng X, Monshouwer M, . . . Naisbitt DJ. (2019)  Toxicological Sciences
  • Click to read the paper

 

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.

  • Thaventhiran T, Wong W, Alghanem AF, Alhumeed N, Aljasir MA, Ramsey S, . . . Sathish JG. (2019)  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  • Click to read the paper

 

Repository Describing an Aging Population to Inform Physiologically Based Pharmacokinetic Models Considering Anatomical, Physiological, and Biological Age-Dependent Changes.

  • Stader F, Siccardi M, Battegay M, Kinvig H, Penny MA, Marzolini C. (2019) Clinical Pharmacokinetics
  • Click to read the paper

 

Software for dosage individualization of voriconazole: A prospective clinical study.

  • Hope W, Johnstone G, Cicconi S, Felton T, Goodwin J, Whalley S, . . . Neely M. (2019) Antimicrobial Agents and Chemotherapy
  • Click to read the paper

 

NAT2 variants and toxicity related to anti-tuberculosis agents: A systematic review and meta-analysis.

  • Richardson M, Kirkham J, Dwan K, Sloan DJ, Davies G, Jorgensen AL. (2019) International Journal of Tuberculosis and Lung Disease
  • Click to read the paper

 

Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites.

  • Decloedt EH, Sinxadi PZ, Van Zyl GU, Wiesner L, Khoo S, Joska JA, . . . Maartens G. (2019)  Journal of Antimicrobial Chemotherapy
  • Click to read the paper

 

Working together to deliver stratified medicine research effectively.

  • Attar SG, Poustie VJ, Smye SW, Beety JM, Hawcutt DB, Littlewood S, . . . Beresford MW. (2019) British Medical Bulletin
  • Click to read the paper

 

Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice.

  • Reade S, Williams JM, Aggio R, Duckworth CA, Mahalhal A, Hough R, . . . Probert CS. (2019)  FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • Click to read the paper

 

Detection of occult neoplastic infiltration in the corpus callosum and prediction of overall survival in patients with glioblastoma using diffusion tensor imaging.

  • Mohan S, Wang S, Coban G, Kural F, Chawla S, O'Rourke DM, Poptani H. (2019)  European Journal of Radiology
  • Click to read the paper

 

Characterisation of a functional rat hepatocyte spheroid model.

  • Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Harding AL, . . . Webb SD. (2019) Toxicology in Vitro
  • Click to read the paper

 

Impact of pharmacogenetics and pregnancy on tenofovir and emtricitabine pharmacokinetics.

  • Gini J, Olagunju A, Dickinson L, Waitt C, Neary M, Else LJ, . . . Khoo S. (2019) Pharmacogenomics
  • Click to read the paper

 

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.

  • Berghuis B, Stapleton C, Sonsma ACM, Hulst J, de Haan GJ, Lindhout D, . . . Rener-Primec Z. (2019)  Epilepsia Open
  • Click to read the paper

 

Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug–drug interaction?

  • Abdullahi ST, Olagunju A, Soyinka JO, Bolarinwa RA, Olarewaju OJ, Bakare-Odunola MT, . . . Khoo S. (2019)  British Journal of Clinical Pharmacology
  • Click to read the paper

 

A Comprehensive Framework for Physiologically-Based Pharmacokinetic Modeling in Matlab.

  • Stader F, Penny MA, Siccardi M, Marzolini C. (2019) CPT: Pharmacometrics and Systems Pharmacology
  • Click to read the paper

 

Therapeutic drug monitoring of darunavir/ritonavir in pregnancy.

  • Murtagh R, Else LJ, Kuan KBK, Khoo SH, Jackson V, Patel A, . . . Lambert JS. (2019)  Antiviral Therapy
  • Click to read the paper

 

Drug interactions between dolutegravir and artemether-lumefantrine or artesunate-amodiaquine.

  • Walimbwa SI, Lamorde M, Waitt C, Kaboggoza J, Else L, Byakika-Kibwika P, . . . Khoo SH. (2019) Antimicrobial Agents and Chemotherapy
  • Click to read the paper

 

Nonmedical prescriber experiences of training and competence to report adverse drug reactions in the UK.

  • Thompson A, Randall C, Howard J, Barker C, Bowden D, Mooney P, . . . Pirmohamed M. (2019)  Journal of Clinical Pharmacy and Therapeutics
  • Click to read the paper

 

Population pharmacodynamics of amphotericin B deoxycholate for disseminated infection caused by talaromyces marneffei.

  • Le T, Ly VT, Thu NTM, Nguyen A, Thanh NT, Chau NVV, . . . Hope W. (2019)  Antimicrobial Agents and Chemotherapy
  • Click to read the paper

 

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.

  • Copple IM, den Hollander W, Callegaro G, Mutter FE, Maggs JL, Schofield AL, . . . Park BK. (2019)  Archives of Toxicology
  • Click to read the paper

 

Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway.

  • Tomlinison, L., Lu, Z. Q., Bentley, R., Colley, H., Murdoch, C., Webb, S., . . . Sharma, P. (2019).  Biomedicine and Pharmacotherapy.
  • Click to read the paper

 

What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England.

  • Giebel C, McIntyre JC, Daras K, Gabbay M, Downing J, Pirmohamed M, . . . Barr B. (2019) BMJ Open
  • Click to read the paper

 

Controversies in drug allergy: Testing for delayed reactions.

  • Phillips EJ, Bigliardi P, Bircher AJ, Broyles A, Chang YS, Chung WH, . . . Barbaud A. (2019) C Journal of Allergy and Clinical Immunology
  • Click to read the paper

 

Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development.

  • Olayanju A, Jones L, Greco K, Goldring CE, Ansari T. (2019) Journal of Applied Toxicology
  • Click to read the paper

 

Seizures and quinolone antibiotics in children: A systematic review of adverse events.

  • Neame M, King C, Riordan A, Iyer A, Kneen R, Sinha I, Hawcutt DB. (2019) European Journal of Hospital Pharmacy
  • Click to read the paper

 

Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin.

  • Navaratnam K, Abreu P, Clarke H, Jorgensen A, Alfirevic A, Alfirevic Z. (2019) Journal of Maternal-Fetal and Neonatal Medicine
  • Click to read the paper

 

Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli.

 

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.

  • Foulkes AC, Watson DS, Carr DF, Kenny JG, Slidel T, Parslew R, . . . Barnes MR. (2019) Journal of Investigative Dermatology
  • Click to read the paper

 

Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis.

 

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