17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use.
(Journal article)
Farzan, N., Vijverberg, S. J., Hernandez-Pacheco, N., Bel, E. H. D., Berce, V., Bønnelykke, K., . . . Maitland-van der Zee, A. -H. (2018). 17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use.. Allergy. DOI: 10.1111/all.13499
A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity
(Journal article)
Leedale, J., Sharkey, K. J., Colley, H. E., Norton, Á. M., Peeney, D., Mason, C. L., . . . Webb, S. D. (2018). A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity. iScience, 4, 84-96. DOI: 10.1016/j.isci.2018.05.012
A Genome-Wide Association Study of Methotrexate-Pneumonitis in Rheumatoid Arthritis: Results from the Pneumonitis Study Consortium
(Conference Paper)
Bluett, J., Owen, S. -A., Massey, J., Plant, D., Pirmohamed, M., Verstappen, S. M. M., & Barton, A. (2016). A Genome-Wide Association Study of Methotrexate-Pneumonitis in Rheumatoid Arthritis: Results from the Pneumonitis Study Consortium. In ARTHRITIS & RHEUMATOLOGY Vol. 68. Retrieved from http://gateway.webofknowledge.com/
Adrenal suppression with inhaled corticosteroids: the seed and the soil reply
(Journal article)
Hawcutt, D. B., Francis, B., & Pirmohamed, M. (2018). Adrenal suppression with inhaled corticosteroids: the seed and the soil reply. LANCET RESPIRATORY MEDICINE, 6(6), E20. Retrieved from http://gateway.webofknowledge.com/
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity
(Journal article)
Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. DOI: 10.1021/acs.chemrestox.8b00030
Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia
(Journal article)
Navaratnam, K., Alfirevic, A., Jorgensen, A., & Alfirevic, Z. (2018). Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 221, 144-150. DOI: 10.1016/j.ejogrb.2017.12.052
Atypical Antipsychotic (AAP)-induced Metabolic Toxicity: Study of Mechanisms, Biomarkers and Reversal Strategies
(Thesis/Dissertation)
Sadiq, S. (2018, January 31). Atypical Antipsychotic (AAP)-induced Metabolic Toxicity:Study of Mechanisms, Biomarkers and Reversal Strategies.
beta-Lactam hypersensitivity involves expansion of circulating and skin-resident T(H)22 cells
(Journal article)
Sullivan, A., Wang, E., Farrell, J., Whitaker, P., Faulkner, L., Peckham, D., . . . Naisbitt, D. J. (2018). beta-Lactam hypersensitivity involves expansion of circulating and skin-resident T(H)22 cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(1), 235-+. DOI: 10.1016/j.jaci.2017.01.020
Biomarkers of adverse drug reactions
(Journal article)
Carr, D. F., & Pirmohamed, M. (2018). Biomarkers of adverse drug reactions. EXPERIMENTAL BIOLOGY AND MEDICINE, 243(3), 291-299. DOI: 10.1177/1535370217733425
Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach.
(Journal article)
Bollegala, D., Maskell, S., Sloane, R., Hajne, J., & Pirmohamed, M. (2018). Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach.. JMIR public health and surveillance, 4(2), e51. DOI: 10.2196/publichealth.8214
Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.
(Journal article)
Dickens, D., Rädisch, S., Chiduza, G. N., Giannoudis, A., Cross, M. J., Malik, H., . . . Nies, A. T. (2018). Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.. Molecular pharmaceutics. DOI: 10.1021/acs.molpharmaceut.8b00547
Childhood asthma exacerbations and ADRB2 polymorphism: Caution is needed Reply
(Journal article)
Turner, S., & Francis, B. (2018). Childhood asthma exacerbations and ADRB2 polymorphism: Caution is needed Reply. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(5), 1955-1956. DOI: 10.1016/j.jaci.2018.01.024
Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update
(Journal article)
Phillips, E. J., Sukasem, C., Whirl-Carrillo, M., Mueller, D. J., Dunnenberger, H. M., Chantratita, W., . . . Pirmohamed, M. (2018). Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103(4), 574-581. DOI: 10.1002/cpt.1004
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
(Journal article)
Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.. Toxicological sciences : an official journal of the Society of Toxicology, 162(2), 655-666.DOI: 10.1093/toxsci/kfx289
Definition of the nature and hapten threshold of the beta-lactam antigen required for T cell activation in vitro and in patients
(Journal article)
Meng, X., Al-Attar, Z., Yaseen, F. S., Jenkins, R., Earnshaw, C., Whitaker, P., . . . Park, B. K. (2018). Definition of the nature and hapten threshold of the beta-lactam antigen required for T cell activation in vitro and in patients (vol 198, pg 4217, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1952. DOI: 10.4049/jimmunol.1800020
Direct oral anticoagulants versus warfarin: is new always better than the old?
(Journal article)
Burn, J., & Pirmohamed, M. (2018). Direct oral anticoagulants versus warfarin: is new always better than the old?. Open heart, 5(1), e000712. DOI: 10.1136/openhrt-2017-000712
Does U=U for breastfeeding mother-infant pairs? Breastfeeding for mothers on effective treatment for HIV infection in high-income settings
(Journal article)
Waitt, C. J., Lowe, N., van de Perre, P., Loutfy, M., Lyon, F., & Aebi-Popp, K. (2018). Does U=U for breastfeeding mother-infant pairs? Breastfeeding for mothers on effective treatment for HIV infection in high-income settings. The Lancet HIV. DOI: 10.1016/S2352-3018(18)30098-5
Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures
(Conference Paper)
Mone, F., Phelan, M., Alfirevic, A., & McAuliffe, F. M. (2018). Evaluating assessments of aspirin adherence in low-risk women for pre-eclampsia prevention: A comparison of crude and objective measures. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 66).
Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis
(Journal article)
Whitfield, J. B., Masson, S., Liangpunsakul, S., Hyman, J., Mueller, S., Aithal, G., . . . Consortium, G. (2018). Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis. ALCOHOL, 66, 1-7. DOI: 10.1016/j.alcohol.2017.07.006
Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue-engineered skin equivalents
(Journal article)
Smith, S. A., Colley, H. E., Sharma, P., Slowik, K. M., Sison-Young, R., Sneddon, A., . . . Murdoch, C. (2018). Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue-engineered skin equivalents. EXPERIMENTAL DERMATOLOGY, 27(5), 473-475. DOI: 10.1111/exd.13483
Genetic and nongenetic factors that may predispose individuals to allergic drug reactions
(Journal article)
Gibson, A., Ogese, M., & Pirmohamed, M. (2018). Genetic and nongenetic factors that may predispose individuals to allergic drug reactions. Current Opinion in Allergy and Clinical Immunology, 1. DOI: 10.1097/ACI.0000000000000459
Genetic factors and response to low dose aspirin in pregnancy
(Conference Paper)
Alfirevic, A., Navaratnam, K., Alfirevic, Z., & Zhang, E. (2018). Genetic factors and response to low dose aspirin in pregnancy. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 125 (pp. 104-105).
Immune drug-induced liver disease and drugs
(Journal article)
Waddington, J. C., Meng, X., Naisbitt, D. J., & Park, B. K. (2018). Immune drug-induced liver disease and drugs. Current Opinion in Toxicology, 10, 46-53. DOI: 10.1016/j.cotox.2017.12.006
Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment
(Journal article)
Kyffin, J. A., Sharma, P., Leedale, J., Colley, H. E., Murdoch, C., Mistry, P., & Webb, S. D. (2018). Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment. TOXICOLOGY IN VITRO, 48, 262-275. DOI: 10.1016/j.tiv.2018.01.023
Implementing Pre-Emptive Pharmacogenomic Testing For A Panel Of Pharmacogenes In The Prepare Study (U-PGX consortium): Results From The First 1,000 Patients
(Conference Paper)
van der Wouden, C. H., Davila-Fajardo, C., Dolzan, V., Patrinos, G. P., Pirmohamed, M., Sunder-Plassmann, G., . . . Guchelaar, H. -J. (2018). IMPLEMENTING PRE-EMPTIVE PHARMACOGENOMIC TESTING FOR A PANEL OF PHARMACOGENES IN THE PREPARE STUDY (U-PGx CONSORTIUM): RESULTS FROM THE FIRST 1,000 PATIENTS.. In CLINICAL PHARMACOLOGY & THERAPEUTICS Vol. 103 (pp. S13).
Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions
(Journal article)
Sullivan, A., Watkinson, J., Waddington, J., Park, B. K., & Naisbitt, D. J. (2018). Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 14(3), 261-274. DOI: 10.1080/17425255.2018.1441285
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms
(Journal article)
Pridgeon, C. S., Schlott, C., Wong, M. W., Heringa, M. B., Heckel, T., Leedale, J., . . . Goldring, C. E. P. (2018). Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms. ARCHIVES OF TOXICOLOGY, 92(2), 557-569. DOI: 10.1007/s00204-018-2152-9
Investigation of Nrf2 activity measures for assessing the toxicological and pharmacological effects of drugs
(Thesis/Dissertation)
Mutter, F. E. M. (2018, June 12). Investigation of Nrf2 activity measures for assessing the toxicological and pharmacological effects of drugs.
Is An Intravenous [14c]Midazolam Microdose Dose-Linear In Children? Results Of A Pilot Study
(Conference Paper)
van Groen, B. D., Park, B. K., Mooij, M. G., Vaes, W., Orgvee, L. -T. K., Maruszak, W., . . . Turner, M. A. (2018). IS AN INTRAVENOUS [14C]MIDAZOLAM MICRODOSE DOSE-LINEAR IN CHILDREN? RESULTS OF A PILOT STUDY.. In CLINICAL PHARMACOLOGY & THERAPEUTICS Vol. 103 (pp. S53).
New uses for old drugs
(Journal article)
Pantziarka, P., Pirmohamed, M., & Mirza, N. (2018). New uses for old drugs. BMJ-BRITISH MEDICAL JOURNAL, 361. DOI: 10.1136/bmj.k2701
NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis
(Journal article)
Lister, A., Bourgeois, S., Silva, P. H. I., Rubio-Aliaga, I., Marbet, P., Walsh, J., . . . Odermatt, A. (2018). NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. SCIENTIFIC REPORTS, 8. DOI: 10.1038/s41598-018-24000-2
Nucleic acid based therapies: developing frontier for precision medicine
(Journal article)
Pirmohamed, M. (2018). Nucleic acid based therapies: developing frontier for precision medicine. BMJ-BRITISH MEDICAL JOURNAL, 360. DOI: 10.1136/bmj.k223
Pharmacogenetics of Adverse Drug Reactions
Osanlou, O., Pirmohamed, M., & Daly, A. K. (2018). Pharmacogenetics of Adverse Drug Reactions. In Advances in Pharmacology (Vol. 83, pp. 155-190). DOI: 10.1016/bs.apha.2018.03.002
Plasma and breast milk pharmacokinetics of emtricitabine, tenofovir and lamivudine using dried blood and breast milk spots in nursing African mother-infant pairs.
(Journal article)
Waitt, C., Olagunju, A., Nakalema, S., Kyohaire, I., Owen, A., Lamorde, M., & Khoo, S. (2018). Plasma and breast milk pharmacokinetics of emtricitabine, tenofovir and lamivudine using dried blood and breast milk spots in nursing African mother-infant pairs. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 73(4), 1013-1019. DOI: 10.1093/jac/dkx507
Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response
(Journal article)
Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., . . . Vimalachandran, D. (2018). Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response. JOURNAL OF PROTEOMICS, 179, 53-60. DOI: 10.1016/j.jprot.2018.02.030
Roles of fibronectin isoforms in neonatal vascular development and matrix integrity
(Journal article)
Kumra, H., Sabatier, L., Hassan, A., Sakai, T., Mosher, D., Brinckmann, J., & Reinhardt, D. (n.d.). Roles of fibronectin isoforms in neonatal vascular development and matrix integrity. PLoS Biology. DOI: 10.1371/journal.pbio.2004812
SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation
(Journal article)
White, K. D., Abe, R., Ardern-Jones, M., Beachkofsky, T., Bouchard, C., Carleton, B., . . . Phillips, E. J. (2018). SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(1), 38-69. DOI: 10.1016/j.jaip.2017.11.023
Status and use of induced pluripotent stem cells (iPSCs) in toxicity testing
(Chapter)
Wong, M. W., Pridgeon, C. S., Schlott, C., Park, B. K., & Goldring, C. E. P. (2018). Status and use of induced pluripotent stem cells (iPSCs) in toxicity testing. In Methods in Pharmacology and Toxicology (pp. 199-212). DOI: 10.1007/978-1-4939-7677-5_10
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study
(Journal article)
Hawcutt, D. B., Francis, B., Carr, D. F., Jorgensen, A. L., Yin, P., Wallin, N., . . . Pirmohamed, M. (2018). Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. LANCET RESPIRATORY MEDICINE, 6(6), 442-450. DOI: 10.1016/S2213-2600(18)30058-4
Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro
(Journal article)
Pushpakom, S. P., Adaikalakoteswari, A., Owen, A., Back, D. J., Tripathi, G., Kumar, S., . . . Pirmohamed, M. (2018). Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro. DIABETES & VASCULAR DISEASE RESEARCH, 15(3), 233-242. DOI: 10.1177/1479164118757924
The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors
(Journal article)
Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. DOI: 10.4049/jimmunol.1800019
The need for patient-tailored dosing of baclofen in future clinical trials Response
(Journal article)
Thompson, A., Pirmohamed, M., Owens, L., & Richardson, P. (2018). The need for patient-tailored dosing of baclofen in future clinical trials Response. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 28(5), 658. DOI: 10.1016/j.euroneuro.2018.03.002
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
(Journal article)
Evans, J. P., Winiarski, B. K., Sutton, P. A., Jones, R. P., Ressel, L., Duckworth, C. A., . . . Kitteringham, N. R. (2018). The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer. Oncotarget, 9(43). DOI: 10.18632/oncotarget.25497
The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy
(Journal article)
Sivapalarajah, S., Krishnakumar, M., Bickerstaffe, H., Chan, Y., Clarkson, J., Hampden-Martin, A., . . . Mirza, N. (2018). The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy. EPILEPSIA, 59(2), 492-501. DOI: 10.1111/epi.13994
The role of SLC4A4 in the pathogenesis of NSAID-induced upper gastrointestinal injury
(Thesis/Dissertation)
Iyinbor, B. (2018). The role of SLC4A4 in the pathogenesis of NSAID-induced upper gastrointestinal injury.
The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death
Kamalian, L., Chadwick, A., Bayliss, M., French, N., Monshouwer, M., Snoeys, J., Park, M. (2018). The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death DOI: 10.1016/j.tiv.2015.02.011
Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice
(Journal article)
Sakabe, T., Sakai, K., Maeda, T., Sunaga, A., Furuta, N., Schweitzer, R., . . . Sakai, T. (2018). Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(16), 5766-5780. DOI: 10.1074/jbc.RA118.001987
Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin
(Journal article)
McWilliam, S. J., Antoine, D. J., Jorgensen, A. L., Smyth, R. L., & Pirmohamed, M. (2018). Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-23466-4 DOI: 10.1038/s41598-018-23466-4
Warfarin: The End or the End of One Size Fits All Therapy?
(Journal article)
Pirmohamed, M. (2018). Warfarin: The End or the End of One Size Fits All Therapy?. Journal of personalized medicine, 8(3). DOI: 10.3390/jpm8030022
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