2016 - Centre for Drug Safety Science - University of Liverpool

A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS)

(Conference Paper)

Cliff, J. R., Carr, D. F., Lord, R. H., Jorgensen, A. L., & Pirmohamed, M. (2016). A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS). In ANNALS OF ONCOLOGY Vol. 27. doi:10.1093/annonc/mdw392.54 DOI: 10.1093/annonc/mdw392.54

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease

(Journal article)

Walker, L. E., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2017). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. BIOMARKERS, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003 DOI: 10.1080/1354750X.2016.1265003

A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat

(Journal article)

Thulin, P., Hornby, R. J., Auli, M., Nordahl, G., Antoine, D. J., Lewis, P. S., . . . Schuppe-Koistinen, I. (2017). A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat. BIOMARKERS, 22(5), 461-469. doi:10.1080/1354750X.2016.1269131 DOI: 10.1080/1354750X.2016.1269131

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

(Journal article)

Sison-Young, R. L., Lauschke, V. M., Johann, E., Alexandre, E., Antherieu, S., Aerts, H., . . . Park, B. K. (2017). A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. ARCHIVES OF TOXICOLOGY, 91(3), 1385-1400. doi:10.1007/s00204-016-1745-4 DOI: 10.1007/s00204-016-1745-4

A multi-factorial analysis of response to warfarin in a UK prospective cohort

(Journal article)

Bourgeois, S., Jorgensen, A., Zhang, E. J., Hanson, A., Gillman, M. S., Bumpstead, S., . . . Pirmohamed, M. (2016). A multi-factorial analysis of response to warfarin in a UK prospective cohort. GENOME MEDICINE, 8. doi:10.1186/s13073-015-0255-y DOI: 10.1186/s13073-015-0255-y

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

(Journal article)

Lundback, P., Lea, J. D., Sowinska, A., Ottosson, L., Furst, C. M., Steen, J., . . . Harris, H. E. (2016). A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice. HEPATOLOGY, 64(5), 1699-1710. doi:10.1002/hep.28736 DOI: 10.1002/hep.28736

A prospective open cohort study examining the effectiveness of Baclofen in AUD patients attending a joint liver and alcohol treatment clinic

(Conference Paper)

Owens, L., Thompson, A., Rose, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2016). A PROSPECTIVE OPEN COHORT STUDY EXAMINING THE EFFECTIVENESS OF BACLOFEN IN AUD PATIENTS ATTENDING A JOINT LIVER AND ALCOHOL TREATMENT CLINIC. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 40 (pp. 275A).

A Randomized Controlled Trial of Extended Brief Intervention for Alcohol-Dependent Patients in an Acute Hospital Setting

(Journal article)

Owens, L., Kolamunnage-Dona, R., Owens, A., Perkins, L., Butcher, G., Wilson, K., . . . Pirmohamed, M. (2016). A Randomized Controlled Trial of Extended Brief Intervention for Alcohol-Dependent Patients in an Acute Hospital Setting. ALCOHOL AND ALCOHOLISM, 51(5), 584-592. doi:10.1093/alcalc/agw023 DOI: 10.1093/alcalc/agw023

A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions

(Journal article)

Plumpton, C. O., Roberts, D., Pirmohamed, M., & Hughes, D. A. (2016). A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions. PHARMACOECONOMICS, 34(8), 771-793. doi:10.1007/s40273-016-0397-9 DOI: 10.1007/s40273-016-0397-9

A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.

(Journal article)

Ghattaoraya, G. S., Dundar, Y., González-Galarza, F. F., Maia, M. H. T., Santos, E. J. M., da Silva, A. L. S., . . . Jones, A. R. (2016). A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.. Database : the journal of biological databases and curation, 2016. doi:10.1093/database/baw069 DOI: 10.1093/database/baw069

Achieving the World Health Organization's vision for clinical pharmacology

(Journal article)

Martin, J. H., Henry, D., Gray, J., Day, R., Bochner, F., Ferro, A., . . . Schwab, M. (2016). Achieving the World Health Organization's vision for clinical pharmacology. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 81(2), 223-227. doi:10.1111/bcp.12803 DOI: 10.1111/bcp.12803

Adrenal responses to a low-dose short synacthen test in children with asthma

(Journal article)

Hawcutt, D. B., Jorgensen, A. L., Wallin, N., Thompson, B., Peak, M., Lacy, D., . . . Smyth, R. L. (2016). Adrenal responses to a low-dose short synacthen test in children with asthma (vol 82, pg 648, 2015). CLINICAL ENDOCRINOLOGY, 84(5), 793. doi:10.1111/cen.13069 DOI: 10.1111/cen.13069

Adverse Drug Reactions in Hospitalised Children

(Thesis/Dissertation)

Thiesen, S. (2016, July 20). Adverse Drug Reactions in Hospitalised Children.

Aminoglycoside-induced nephrotoxicity in children

(Journal article)

McWilliam, S. J., Antoine, D. J., Smyth, R. L., & Pirmohamed, M. (2017). Aminoglycoside-induced nephrotoxicity in children. PEDIATRIC NEPHROLOGY, 32(11), 2015-2025. doi:10.1007/s00467-016-3533-z DOI: 10.1007/s00467-016-3533-z

Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients

(Journal article)

Meng, X., Earnshaw, C. J., Tailor, A., Jenkins, R. E., Waddington, J. C., Whitaker, P., . . . Park, B. K. (2016). Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients. CHEMICAL RESEARCH IN TOXICOLOGY, 29(10), 1762-1772. doi:10.1021/acs.chemrestox.6b00253 DOI: 10.1021/acs.chemrestox.6b00253

Application of Pluripotent Stem Cells in Drug-Induced Liver Injury Safety Assessment

(Chapter)

Pridgeon, C. S., Zhang, F., Heslop, J. A., Nugues, C. M. L., Kitteringham, N. R., Park, B. K., & Goldring, C. E. P. (2016). Application of Pluripotent Stem Cells in Drug-Induced Liver Injury Safety Assessment. In Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers (pp. 331-345). doi:10.1002/9781119053248.ch21 DOI: 10.1002/9781119053248.ch21

An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters

(Journal article)

Mirza, N., Vasieva, O., Appleton, R., Burn, S., Carr, D., Crooks, D., . . . Pirmohamed, M. (2016). An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters. EPILEPSIA, 57(9), 1467-1474. doi:10.1111/epi.13473 DOI: 10.1111/epi.13473

Anti-CD3 antibody induces T-cell mediated apoptosis and shedding of murine small intestinal epithelial cells

(Conference Paper)

Elramli, A. H., Duckworth, C. A., Campbell, B. J., & Pritchard, D. M. (2016). ANTI-CD3 ANTIBODY INDUCES T-CELL MEDIATED APOPTOSIS AND SHEDDING OF MURINE SMALL INTESTINAL EPITHELIAL CELLS. In GUT Vol. 65 (pp. A75). doi:10.1136/gutjnl-2016-312388.134 DOI: 10.1136/gutjnl-2016-312388.134

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study

(Journal article)

Nicoletti, P., Aithal, G. P., Bjornsson, E. S., Andrade, R. J., Sawle, A., Arrese, M., . . . Consort, I. S. A. E. (2017). Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study. GASTROENTEROLOGY, 152(5), 1078-1089. doi:10.1053/j.gastro.2016.12.016 DOI: 10.1053/j.gastro.2016.12.016

Carbamazepine Hypersensitivity: Linking Metabolism to the Immune Response

(Thesis/Dissertation)

Yip, V. L. M. (2016, July 11). Carbamazepine Hypersensitivity: Linking Metabolism to the Immune Response.

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

(Journal article)

Ravenscroft, S. M., Pointon, A., Williams, A. W., Cross, M. J., & Sidaway, J. E. (2016). Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues. TOXICOLOGICAL SCIENCES, 152(1), 99-112. doi:10.1093/toxsci/kfw069 DOI: 10.1093/toxsci/kfw069

Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability

(Journal article)

Wilkinson, E. L., Sidaway, J. E., & Cross, M. J. (2016). Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability. BIOLOGY OPEN, 5(10), 1362-1370. doi:10.1242/bio.020362 DOI: 10.1242/bio.020362

Characterization of a functional C3A liver spheroid model

(Journal article)

Gaskell, H., Sharma, P., Colley, H. E., Murdoch, C., Williams, D. P., & Webb, S. D. (2016). Characterization of a functional C3A liver spheroid model. TOXICOLOGY RESEARCH, 5(4), 1053-1065. doi:10.1039/c6tx00101g DOI: 10.1039/c6tx00101g

Characterisation of Drug-Specific T-Cell Responses in Hypersensitive Patients and Healthy Donors

(Thesis/Dissertation)

Al-Attar, Z. I. (2016, September 13). Characterisation of Drug-Specific T-Cell Responses in Hypersensitive Patients and Healthy Donors.

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(Journal article)

Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., . . . Ingelman-Sundberg, M. (2016). Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. SCIENTIFIC REPORTS, 6. doi:10.1038/srep25187 DOI: 10.1038/srep25187

Childhood asthma exacerbations and the Arg16 beta(2)-receptor polymorphism: A meta-analysis stratified by treatment

(Journal article)

Turner, S., Francis, B., Vijverberg, S., Pino-Yanes, M., Maitland-van der Zee, A. H., Basu, K., . . . Asthma, P. C. (2016). Childhood asthma exacerbations and the Arg16 beta(2)-receptor polymorphism: A meta-analysis stratified by treatment. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(1), 107-+. doi:10.1016/j.jaci.2015.10.045 DOI: 10.1016/j.jaci.2015.10.045

Composition and Function of the Extracellular Matrix in the Human Body

(Book)

Sakai, T. (2016). Composition and Function of the Extracellular Matrix in the Human Body. F. Travascio (Ed.), InTech.

Co-precipitation of DEAE-dextran coated SPIONs: how synthesis conditions affect particle properties, stem cell labelling and MR contrast

(Journal article)

Barrow, M., Taylor, A., Carrion, J. G., Mandal, P., Park, B. K., Poptani, H., . . . Adams, D. J. (2016). Co-precipitation of DEAE-dextran coated SPIONs: how synthesis conditions affect particle properties, stem cell labelling and MR contrast. CONTRAST MEDIA & MOLECULAR IMAGING, 11(5), 362-370. doi:10.1002/cmmi.1700 DOI: 10.1002/cmmi.1700

Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden

(Journal article)

Verhoef, T. I., Redekop, W. K., Langenskiold, S., Kamali, F., Wadelius, M., Burnside, G., . . . Pirmohamed, M. (2016). Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden. PHARMACOGENOMICS JOURNAL, 16(5), 478-484. doi:10.1038/tpj.2016.41 DOI: 10.1038/tpj.2016.41

CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF

(Journal article)

Nightingale, S., Michael, B. D., Fisher, M., Winston, A., Nelson, M., Taylor, S., . . . Solomon, T. (2016). CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF. CYTOKINE, 83, 139-146. doi:10.1016/j.cyto.2016.04.004 DOI: 10.1016/j.cyto.2016.04.004

Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats

(Journal article)

Richert, L., Baze, A., Parmentier, C., Gerets, H. H. J., Sison-Young, R., Dorau, M., . . . Williams, D. P. (2016). Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats. TOXICOLOGY LETTERS, 258, 207-215. doi:10.1016/j.toxlet.2016.06.1127 DOI: 10.1016/j.toxlet.2016.06.1127

Defining drug response for stratified medicine.

(Journal article)

Lonergan, M., Senn, S. J., McNamee, C., Daly, A. K., Sutton, R., Hattersley, A., . . . Pirmohamed, M. (2017). Defining drug response for stratified medicine. DRUG DISCOVERY TODAY, 22(1), 173-179. doi:10.1016/j.drudis.2016.10.016 DOI: 10.1016/j.drudis.2016.10.016

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites

(Journal article)

Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., . . . Park, B. K. (2016). Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites. JOURNAL OF MEDICINAL CHEMISTRY, 59(6), 2396-2409. doi:10.1021/acs.jmedchem.5b01292 DOI: 10.1021/acs.jmedchem.5b01292

Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21,-200c, and-423

(Journal article)

Pavkovic, M., Robinson-Cohen, C., Chua, A. S., Nicoara, O., Cardenas-Gonzalez, M., Bijol, V., . . . Vaidya, V. S. (2016). Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21,-200c, and-423. TOXICOLOGICAL SCIENCES, 152(1), 205-213. doi:10.1093/toxsci/kfw077 DOI: 10.1093/toxsci/kfw077

Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury

(Journal article)

Usui, T., Whitaker, P., Meng, X., Watson, J., Antoine, D. J., French, N. S., . . . Naisbitt, D. J. (2016). Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(11), 1793-1795. doi:10.1021/acs.chemrestox.6b00393 DOI: 10.1021/acs.chemrestox.6b00393

Detection of drug-responsive B lymphocytes and antidrug IgG in patients with beta-lactam hypersensitivity

(Journal article)

Amali, M. O., Sullivan, A., Jenkins, R. E., Farrell, J., Meng, X., Faulkner, L., . . . Naisbitt, D. J. (2017). Detection of drug-responsive B lymphocytes and antidrug IgG in patients with beta-lactam hypersensitivity. ALLERGY, 72(6), 896-907. doi:10.1111/all.13087 DOI: 10.1111/all.13087

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

(Journal article)

Faulkner, L., Gibson, A., Sullivan, A., Tailor, A., Usui, T., Alfirevic, A., . . . Park, B. K. (2016). Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. TOXICOLOGICAL SCIENCES, 154(2), 416-429. doi:10.1093/toxsci/kfw177 DOI: 10.1093/toxsci/kfw177

Development of a Spheroid Model to Investigate Drug-Induced Liver Injury

(Thesis/Dissertation)

Gaskell, H. (2016, August 5). Development of a Spheroid Model to Investigate Drug-Induced Liver Injury.

Developments in Cardiovascular Proteomics

(Journal article)

A Noronha, M., & Linden, C. (2016). Developments in Cardiovascular Proteomics. Journal of Proteomics & Bioinformatics, 09(05). doi:10.4172/jpb.1000400 DOI: 10.4172/jpb.1000400

Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia

(Journal article)

Nightingale, S., Geretti, A. M., Beloukas, A., Fisher, M., Winston, A., Else, L., . . . Khoo, S. (2016). Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia. JOURNAL OF NEUROVIROLOGY, 22(6), 852-860. doi:10.1007/s13365-016-0448-1 DOI: 10.1007/s13365-016-0448-1

Back to: Centre for Drug Safety Science

Dosing antiretroviral medication when crossing time zones: a review

(Journal article)

Lewis, J. M., Volny-Anne, A., Waitt, C., Boffito, M., & Khoo, S. (2016). Dosing antiretroviral medication when crossing time zones: a review. AIDS, 30(2), 267-271. doi:10.1097/QAD.0000000000000920 DOI: 10.1097/QAD.0000000000000920

Drug-specific CD4(+) T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome

(Journal article)

Ye, Y. -M., Hur, G. -Y., Kim, S. -H., Ban, G. -Y., Jee, Y. -K., Naisbitt, D. J., . . . Kim, S. -H. (2017). Drug-specific CD4(+) T-cell immune responses are responsible for antituberculosis drug-induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome. BRITISH JOURNAL OF DERMATOLOGY, 176(2), 378-386. doi:10.1111/bjd.14839 DOI: 10.1111/bjd.14839

Drug transporters at the blood-brain barrier

(Chapter)

Dickens, D., Radisch, S., & Pirmohamed, M. (2016). Drug transporters at the blood-brain barrier. In RSC Drug Discovery Series (Vol. 2016-January, pp. 151-183). doi:10.1039/9781782623793-00151

DOI: 10.1039/9781782623793-00151

Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis

(Journal article)

Nightingale, S., Chau, T. T. H., Fisher, M., Nelson, M., Winston, A., Else, L., . . . Grp, P. -V. S. (2016). Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(8), 4511-4518. doi:10.1128/AAC.00280-16 DOI: 10.1128/AAC.00280-16

Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis

(Journal article)

Spriggs, S., Sheffield, D., Olayanju, A., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2016). Effect of Repeated Daily Dosing with 2,4-Dinitrochlorobenzene on Glutathione Biosynthesis and Nrf2 Activation in Reconstructed Human Epidermis. TOXICOLOGICAL SCIENCES, 154(1), 5-15. doi:10.1093/toxsci/kfw140 DOI: 10.1093/toxsci/kfw140

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

(Journal article)

Dragovic, S., Vermeulen, N. P. E., Gerets, H. H., Hewitt, P. G., Ingelman-Sundberg, M., Park, B. K., . . . Weaver, R. J. (2016). Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man. ARCHIVES OF TOXICOLOGY, 90(12), 2979-3003. doi:10.1007/s00204-016-1845-1 DOI: 10.1007/s00204-016-1845-1

From mice to men: Murine models of colorectal cancer for use in translational research

(Journal article)

Evans, J. P., Sutton, P. A., Winiarski, B. K., Fenwick, S. W., Malik, H. Z., Vimalachandran, D., . . . Kitteringham, N. R. (2016). From mice to men: Murine models of colorectal cancer for use in translational research. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 98, 94-105. doi:10.1016/j.critrevonc.2015.10.009 DOI: 10.1016/j.critrevonc.2015.10.009

Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia

(Journal article)

Legge, S. E., Hamshere, M. L., Ripke, S., Pardinas, A. F., Goldstein, J. I., Rees, E., . . . Walters, J. T. R. (2017). Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Molecular Psychiatry, 22(10), 1502-1508. doi:10.1038/mp.2016.97 DOI: 10.1038/mp.2016.97

Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy

(Journal article)

Kuzmanov, U., Guo, H., Buchsbaum, D., Cosme, J., Abbasi, C., Isserlin, R., . . . Emili, A. (2016). Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(44), 12592-12597. doi:10.1073/pnas.1606444113 DOI: 10.1073/pnas.1606444113

HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis

(Journal article)

Cheung, C. -L., Sing, C. -W., Tang, C. S. M., Cheng, V. K. F., Pirmohamed, M., Choi, C. -H., . . . Kung, A. W. C. (2016). HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis. CLINICAL PHARMACOLOGY & THERAPEUTICS, 99(5), 555-561. doi:10.1002/cpt.309 DOI: 10.1002/cpt.309

HLA-B*38:02:01 predicts carbimazole/methimazole-induced agranulocytosis

(Journal article)

Cheung, C. -L., Sing, C. -W., Tang, C. S. M., Cheng, V. K. F., Pirmohamed, M., Choi, C. -H., . . . Kung, A. W. C. (2016). HLA-B*38:02:01 predicts carbimazole/methimazole-induced agranulocytosis. CHEMICAL BIOLOGY & DRUG DESIGN, 99(5), 555-561. doi:10.1002/cpt.309 DOI: 10.1002/cpt.309

Human leukocyte antigen and idiosyncratic adverse drug reactions

(Journal article)

Usui, T., & Naisbitt, D. J. (2017). Human leukocyte antigen and idiosyncratic adverse drug reactions. DRUG METABOLISM AND PHARMACOKINETICS, 32(1), 21-30. doi:10.1016/j.dmpk.2016.11.003 DOI: 10.1016/j.dmpk.2016.11.003

Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients

(Journal article)

Qin, S., Zhou, Y., Gray, L., Kusebauch, U., McEvoy, L., Antoine, D. J., . . . Hood, L. (2016). Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients. JOURNAL OF PROTEOME RESEARCH, 15(10), 3724-3740. doi:10.1021/acs.jproteome.6b00547 DOI: 10.1021/acs.jproteome.6b00547

Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells

(Journal article)

Ball, A. L., Kamalian, L., Alfirevic, A., Lyon, J. J., & Chadwick, A. E. (2016). Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells. TOXICOLOGICAL SCIENCES, 153(2), 341-351. doi:10.1093/toxsci/kfw126 DOI: 10.1093/toxsci/kfw126

Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease

(Journal article)

Sharkey, J., Scarfe, L., Santeramo, I., Garcia-Finana, M., Park, B. K., Poptani, H., . . . Murray, P. (2016). Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease. EUROPEAN JOURNAL OF PHARMACOLOGY, 790, 74-82. doi:10.1016/j.ejphar.2016.06.056 DOI: 10.1016/j.ejphar.2016.06.056

Immunological Mechanisms of Drug Hypersensitivity

(Journal article)

Meng, X., Ariza, A., Waddington, J., Park, K., & Naisbitt, D. (2016). Immunological Mechanisms of Drug Hypersensitivity. CURRENT PHARMACEUTICAL DESIGN, 22(45), 6734-6747. doi:10.2174/1381612822666161003115103 DOI: 10.2174/1381612822666161003115103

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.

(Journal article)

van der Wouden, C. H., Cambon-Thomsen, A., Cecchin, E., Cheung, K. C., Davila-Fajardo, C. L., Deneer, V. H., . . . Consor, U. P. (2017). Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium. CLINICAL PHARMACOLOGY & THERAPEUTICS, 101(3), 341-358. doi:10.1002/cpt.602 DOI: 10.1002/cpt.602

Importance of the alternative NF-kappa B activation pathway in inflammation-associated gastrointestinal carcinogenesis

(Journal article)

Merga, Y. J., O'Hara, A., Burkitt, M. D., Duckworth, C. A., Probert, C. S., Campbell, B. J., & Pritchard, D. M. (2016). Importance of the alternative NF-kappa B activation pathway in inflammation-associated gastrointestinal carcinogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 310(11), G1081-G1090. doi:10.1152/ajpgi.00026.2016 DOI: 10.1152/ajpgi.00026.2016

Intestinal Preparation Techniques for Histological Analysis in the Mouse.

(Journal article)

Williams, J. M., Duckworth, C. A., Vowell, K., Burkitt, M. D., & Pritchard, D. M. (2016). Intestinal Preparation Techniques for Histological Analysis in the Mouse.. Current protocols in mouse biology, 6(2), 148-168. doi:10.1002/cpmo.2 DOI: 10.1002/cpmo.2

Intracellular and extracellular biomarkers of drug-induced liver injury

(Thesis/Dissertation)

Hornby, R. (2016). INTRACELLULAR AND EXTRACELLULAR BIOMARKERS OF DRUG-INDUCED LIVER INJURY. (University of Liverpool).

Investigating the impact of OCT transporter genotype on metformin-induced vitamin B12 deficiency

(Thesis/Dissertation)

Green, L. A. (2016, September 30). Investigating the impact of OCT transporter genotype on metformin-induced vitamin B12 deficiency.

Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome

(Journal article)

Turner, R. M., Yin, P., Hanson, A., FitzGerald, R., Morris, A. P., Stables, R. H., . . . Pirmohamed, M. (2017). Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome. JOURNAL OF CLINICAL LIPIDOLOGY, 11(1), 204-214. doi:10.1016/j.jacl.2016.12.007 DOI: 10.1016/j.jacl.2016.12.007

Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis

(Journal article)

Fjeld, K., Beer, S., Johnstone, M., Zimmer, C., Moessner, J., Ruffert, C., . . . Rosendahl, J. (2016). Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. PLOS ONE, 11(11). doi:10.1371/journal.pone.0165567 DOI: 10.1371/journal.pone.0165567

Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking

(Journal article)

Sasaki, T., Stoop, R., Sakai, T., Hess, A., Deutzmann, R., Schloetzer-Schrehardt, U., . . . von der Mark, K. (2016). Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking. MATRIX BIOLOGY, 50, 53-66. doi:10.1016/j.matbio.2015.12.002 DOI: 10.1016/j.matbio.2015.12.002

Low dose aspirin and pregnancy: how important is aspirin resistance?

(Journal article)

Navaratnam, K., Alfirevic, A., & Alfirevic, Z. (2016). Low dose aspirin and pregnancy: how important is aspirin resistance?. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 123(9), 1481-1487. doi:10.1111/1471-0528.13914 DOI: 10.1111/1471-0528.13914

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(Journal article)

Nielsen, S. R., Quaranta, V., Linford, A., Emeagi, P., Rainer, C., Santos, A., . . . Schmid, M. C. (2016). Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. NATURE CELL BIOLOGY, 18(5), 549-+. doi:10.1038/ncb3340 DOI: 10.1038/ncb3340

Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation

(Journal article)

Tailor, A., Waddington, J. C., Meng, X., & Park, B. K. (2016). Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 1912-1935. doi:10.1021/acs.chemrestox.6b00147 DOI: 10.1021/acs.chemrestox.6b00147

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

(Journal article)

Lauschke, V. M., Vorrink, S. U., Moro, S. M. L., Rezayee, F., Nordling, A., Hendriks, D. F. G., . . . Ingelman-Sundberg, M. (2016). Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation. HEPATOLOGY, 64(5), 1743-1756. doi:10.1002/hep.28780 DOI: 10.1002/hep.28780

Mechanisms of Collagen Network Organization in Response to Tissue/Organ Damage

(Book)

Sakai, T. (2016). Mechanisms of Collagen Network Organization in Response to Tissue/Organ Damage. F. Travascio (Ed.), InTech.

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

(Journal article)

Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Park, B. K. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. ARCHIVES OF TOXICOLOGY, 91(1), 439-452. doi:10.1007/s00204-016-1694-y DOI: 10.1007/s00204-016-1694-y

Mist and the future

(Chapter)

Park, B. K., & Smith, D. A. (2016). Mist and the future. In Metabolite Safety in Drug Development (pp. 305-322). doi:10.1002/9781118949689.ch14 DOI: 10.1002/9781118949689.ch14

Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis

(Journal article)

Saneyasu, T., Akhtar, R., & Sakai, T. (2016). Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis. BIOMED RESEARCH INTERNATIONAL. doi:10.1155/2016/2646212 DOI: 10.1155/2016/2646212

Molecular mechanism responsible for collagenous matrix accumulation during chronic hepatic fibrogenesis

(Conference Paper)

Sakai, T. (2016). Molecular mechanism responsible for collagenous matrix accumulation during chronic hepatic fibrogenesis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A5).

Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis

(Journal article)

Iwasaki, A., Sakai, K., Moriya, K., Sasaki, T., Keene, D. R., Akhtar, R., . . . Sakai, T. (2016). Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(1), 72-88. doi:10.1074/jbc.M115.691519 DOI: 10.1074/jbc.M115.691519

Nephrotoxicity in Children Receiving Chemotherapy - 'Omics and Biomarkers

(Conference Paper)

Barton, C., Pizer, B., Hawcutt, D., Pirmohamed, M., Hemsworth, S., & Hincks, E. (2016). Nephrotoxicity in Children Receiving Chemotherapy - 'Omics and Biomarkers. In PEDIATRIC BLOOD & CANCER Vol. 63 (pp. S121-S122).

No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury

(Journal article)

Faulkner, L., Meng, X., Naisbitt, D. J., Spraggs, C. F., & Park, B. K. (2016). No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury. CHEMICAL RESEARCH IN TOXICOLOGY, 29(12), 2111-2113. doi:10.1021/acs.chemrestox.6b00400 DOI: 10.1021/acs.chemrestox.6b00400

Open letter on access to the BIA 10-2474 clinical trial data

(Journal article)

Brosen, K., Funck-Brentano, C., Kroemer, H. K., Pirmohamed, M., & Schwab, M. (2017). Open letter on access to the BIA 10-2474 clinical trial data. LANCET, 389(10065), 156. doi:10.1016/S0140-6736(16)32515-6 DOI: 10.1016/S0140-6736(16)32515-6

Paediatric adverse drug reactions (ADRS): a comparison of a newly developed avoidability tool to existing Hallas assessments

(Poster)

Bracken, L., Kirkham, J., Nunn, A., Pirmohamed, M., Peak, M., & Turner, M. (2016). PAEDIATRIC ADVERSE DRUG REACTIONS (ADRS): A COMPARISON OF A NEWLY DEVELOPED AVOIDABILITY TOOL TO EXISTING HALLAS ASSESSMENTS.. Poster session presented at the meeting of Unknown Conference. DOI: 10.1136/archdischild-2016-311535.72

Personalized Medicine in Cardiovascular Disease

(Chapter)

Turner, R., Bula, M., & Pirmohamed, M. (2016). Personalized Medicine in Cardiovascular Disease. In W. B. Coleman, & G. J. Tsongalis (Eds.), Diagnostic Molecular Pathology A Guide to Applied Molecular Testing (pp. 457-471). Academic Press.

Pharmacogenetics and Pharmacogenomics

(Chapter)

Alfirevic, A., & Pirmohamed, M. (2016). Pharmacogenetics and Pharmacogenomics. In Medical and Health Genomics (pp. 121-137). doi:10.1016/B978-0-12-420196-5.00010-1 DOI: 10.1016/B978-0-12-420196-5.00010-1

Pivotal role of NFATc4 in antiretroviral-induced adipocyte toxicity

(Poster)

Majid, R., Pushpakom, S., & Pirmohamed, M. (2016). Pivotal role of NFATc4 in antiretroviral-induced adipocyte toxicity. Poster session presented at the meeting of Unknown Conference.

Precision Dosing in Children

(Journal article)

Hawcutt, D. B., Cooney, L., Oni, L., & Pirmohamed, M. (2016). Precision Dosing in Children. Expert Review of Precision Medicine and Drug Development, 1(1), 69-78. doi:10.1080/23808993.2016.1138845 DOI: 10.1080/23808993.2016.1138845

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo

(Journal article)

Comenge, J., Fragueiro, O., Sharkey, J., Taylor, A., Held, M., Burton, N. C., . . . Levy, R. (2016). Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. ACS Nano, 10(7), 7106-7116. doi:10.1021/acsnano.6b03246 DOI: 10.1021/acsnano.6b03246

Progress in pharmacogenetics: consortiums and new strategies

(Journal article)

Maroñas, O., Latorre, A., Dopazo, J., Pirmohamed, M., Rodríguez-Antona, C., Siest, G., . . . LLerena, A. (2016). Progress in pharmacogenetics: consortiums and new strategies.. Drug metabolism and personalized therapy, 31(1), 17-23. doi:10.1515/dmpt-2015-0039 DOI: 10.1515/dmpt-2015-0039

Roles of Nrf2 in drug and chemical toxicity

(Journal article)

Clarke, J. L., Murray, J. B., Park, B. K., & Copple, I. M. (2016). Roles of Nrf2 in drug and chemical toxicity. Current Opinion in Toxicology, 1, 104-110. doi:10.1016/j.cotox.2016.10.004 DOI: 10.1016/j.cotox.2016.10.004

SNP-Treatment Interactions of Cardiovascular Medications and Risk of Acute Coronary Syndrome Recurrence

(Conference Paper)

Yin, P., Jorgensen, A., Morris, A., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2016). SNP-Treatment Interactions of Cardiovascular Medications and Risk of Acute Coronary Syndrome Recurrence. In GENETIC EPIDEMIOLOGY Vol. 40 (pp. 672).

Semi-systematic review of definitions and diagnostic tests for aspirin resistance: an opportunity to stratify prevention of placental disease

(Conference Paper)

Navaratnam, K., Alfirevic, A., & Alfirevic, Z. (2016). Semi-systematic review of definitions and diagnostic tests for aspirin resistance: an opportunity to stratify prevention of placental disease. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 123 (pp. E10-E11).

Spontaneous adverse drug reaction reports for neonates and infants in the UK 2001-2010: content and utility analysis

(Journal article)

Hawcutt, D. B., Russell, N. -J., Maqsood, H., Kouranloo, K., Gomberg, S., Waitt, C., . . . Turner, M. A. (2016). Spontaneous adverse drug reaction reports for neonates and infants in the UK 2001-2010: content and utility analysis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 82(6), 1601-1612. doi:10.1111/bcp.13067 DOI: 10.1111/bcp.13067

Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury

(Journal article)

Goldring, C., Antoine, D. J., Bonner, F., Crozier, J., Denning, C., Fontana, R. J., . . . Park, B. K. (2017). Stem Cell-Derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-Induced Liver Injury. HEPATOLOGY, 65(2), 710-721. doi:10.1002/hep.28886 DOI: 10.1002/hep.28886

The hepatic adaptive response to repeat acetaminophen exposure

(Thesis/Dissertation)

Eakins, R. M. (2016, February). The hepatic adaptive response to repeat acetaminophen exposure.

The potential role of liver sinusoidal endothelial cells in drug-induced liver injury

(Thesis/Dissertation)

Akingbasote, J. A. (2016, November 15). THE POTENTIAL ROLE OF LIVER SINUSOIDAL ENDOTHELIAL CELLS INDRUG-INDUCED LIVER INJURY.

The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review

(Journal article)

Lees, E. A., Miyajima, F., Pirmohamed, M., & Carrol, E. D. (2016). The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 35(7), 1047-1057. doi:10.1007/s10096-016-2639-3 DOI: 10.1007/s10096-016-2639-3

The role of ERK5 in tumour angiogenesis and drug resistance

(Thesis/Dissertation)

Aljasir, M. A. (2016, October 10). The role of ERK5 in tumour angiogenesis and drug resistance.

The Role of T-helper 17 and T-helper 22 Lymphocytes in Beta-Lactam Hypersensitivity

(Thesis/Dissertation)

Sullivan, A. D. (2016, June 30). The Role of T-helper 17 and T-helper 22 Lymphocytes in Beta-Lactam Hypersensitivity.

Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study

(Journal article)

Fung, P. P. L., Bedogni, G., Bedogni, A., Petrie, A., Porter, S., Campisi, G., . . . Consortium, G. E. N. V. A. B. O. (2017). Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study. ORAL DISEASES, 23(4), 477-483. doi:10.1111/odi.12632 DOI: 10.1111/odi.12632

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis

(Journal article)

Abu-Alainin, W., Gana, T., Liloglou, T., Olayanju, A., Barrera, L. N., Ferguson, R., . . . Costello, E. (2016). UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis. JOURNAL OF PATHOLOGY, 238(3), 423-433. doi:10.1002/path.4665 DOI: 10.1002/path.4665

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury

(Journal article)

Kim, S. -H., & Naisbitt, D. J. (2016). Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury. ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 8(1), 3-11. doi:10.4168/aair.2016.8.1.3 DOI: 10.4168/aair.2016.8.1.3

Utilisation of an in vitro T-cell priming assay to characterise the effects of co-inhibitory signalling on the activation of antigen-specific T-cells.

(Thesis/Dissertation)

Gibson, A. (2015, December 18). Utilisation of an in vitro T-cell priming assay to characterise the effects of co-inhibitory signalling on the activation of antigen-specific T-cells.