We have one of the largest international bioresources of samples, including DNA, biofluids, and tissue biopsies, from 18,933 ADR patients. The rare nature of many of the ADRs that we study means that we must recruit patients regionally and nationally. We have therefore opened a total of 451 study-specific sites across the UK under CDSS ethics.
|
Study Description |
Sites (n) |
Patients (n) |
Bioresource |
|
Antipsychotic-induced cardiometabolic toxicity |
3 |
50 |
DNA; plasma/serum; urine |
|
ABC transporters in paediatric IBD |
1 |
61 |
|
|
Biomarkers of Paracetamol hepatotoxicity |
12 |
402 |
DNA; plasma/serum; urine |
|
Clostridium Difficile predisposition Study |
5 |
1208 |
DNA; plasma/serum; urine; PBMC; stool |
|
Various international research and industrial collaborations on drug hypersensitivity. |
2 |
200 |
DNA; plasma/serum; PBMCs; skin biopsy |
|
Folic acid adjuvant to anti-depressant therapy. |
3 |
576 |
DNA |
|
Genotyped Healthy volunteers for phase I clinical studies |
18 |
3047 |
DNA; plasma |
|
HLA-typed healthy volunteers |
1 |
1218 |
DNA; PBMCs |
|
Drug Hypersensitivity study (HYST) |
9 |
159 |
DNA; plasma/serum; urine; PBMC; stool; various tissue biopsies |
|
IFN-β Hypersensitivity in multiple sclerosis |
2 |
30 |
DNA |
|
Molecular genetics of ADRs in children |
11 |
564 |
DNA |
|
Methadone PgX of dose and ADRs |
3 |
250 |
DNA; saliva |
|
Molecular Genetics of ADRs (including Drug Hypersensitivity study, HYST) |
183 |
2429 |
DNA; plasma/serum; urine; PBMC; stool; various tissue biopsies |
|
NSAID-induced gastric ulceration |
15 |
1469 |
DNA; plasma/serum; urine; antrum and ulcer biopsy |
|
PGx of Adrenal Suppression with Inhaled steroids in COPD |
16 |
291 |
DNA; plasma/serum |
|
PGx of Adrenal Suppression with Inhaled steroids in asthma |
3 |
600 |
DNA; plasma/serum; saliva |
|
Role of Porphyrins in Anti-Tuberculous Drug-Induced Liver Injury |
4 |
35 |
DNA; plasma/serum; urine |
|
Dosing algorithms in warfarin extreme responder phenotypes |
9 |
349 |
DNA |
|
Pharmacology Biobank |
1 |
368 |
DNA; PBMC; plasma/serum |
|
Pharmacogenomics of Acute Coronary Syndrome |
18 |
1561 |
DNA; plasma/serum |
|
Clinical Implementation of pre-emptive PGx testing |
2 |
621 |
DNA; saliva |
|
Statin-induced myopathy from CPRD |
141 |
975 |
DNA; plasma/serum; urine; saliva |
|
PGx of tamoxifen response in breast cancer |
2 |
89 |
DNA |
|
NHS Chair Warfarin PGx study and PGX approach to coumarin anticoagulant therapy |
12 |
2006 |
DNA; plasma/serum |
|
Warfarin anticoagulation in patients in Sub-Saharan Africa |
2 |
274 |
DNA |
|
Warfarin dosing and PGx in paediatrics |
2 |
101 |
DNA |
For more information on any of these resources please contact us at cdss@liverpool.ac.uk